2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole

Base Information

• Chemical Name: 2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole
• CAS No.: 96159-88-5
• Molecular Formula: C9H8N2O2S
• Molecular Weight: 208.241
• Mol file: 96159-88-5.mol

Synonyms:Thiazole,4,5-dihydro-2-(3-nitrophenyl);4,5-Dihydro-2-(3-nitrophenyl)thiazole;2-{3-nitrophenyl}-4,5-dihydro-1,3-thiazole;

Chemical Property of 2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole

Chemical Property:

• Vapor Pressure: 3.39E-05mmHg at 25°C
• Boiling Point: 365°Cat760mmHg
• Flash Point: 174.6°C
• PSA: 83.48000
• Density: 1.43g/cm³
• LogP: 2.04700

Purity/Quality:

2-(3-NITROPHENYL)-4,5-DIHYDRO-1,3-THIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole

There total 4 articles about 2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Cysteamine (60-23-1) + 3-nitrobenzonitrile (619-24-9) → 2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole (96159-88-5)

Guidance literature:

With trichloroisocyanuric acid; In neat (no solvent); at 110 ℃; for 0.0333333h; chemoselective reaction;

DOI:10.2298/JSC111031028H

Reference yield: 96.0%

3-nitrothiobenzamide (70102-34-0) + 2-bromoethylamine hydrobromide (2576-47-8) → 2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole (96159-88-5)

Guidance literature:

3-nitrothiobenzamide; 2-bromoethylamine hydrobromide; In water; at 60 - 70 ℃; for 4h;

With sodium carbonate; In water;

DOI:10.1039/c1gc15285h

Reference yield: 85.0%

3-nitrobenzaldoxime (3431-62-7,20747-39-1) + N-(2-bromoethyl)dichlorothiophosphoramidate → 2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole (96159-88-5)

Guidance literature:

With water; triethylamine; In neat (no solvent); at 0 - 120 ℃; Green chemistry;

DOI:10.1055/s-0035-1560459

upstream raw materials:

2-phenylthiazoline

Cysteamine

3-nitrobenzonitrile

3-nitrothiobenzamide