70102-34-0

Usage

Uses

Used in Organic Synthesis:
3-NITRO-THIOBENZAMIDE is used as a reagent in organic synthesis for its ability to participate in a range of chemical reactions, facilitating the creation of diverse chemical products.
Used in Pharmaceutical Research and Development:
In the pharmaceutical industry, 3-NITRO-THIOBENZAMIDE is utilized as a key intermediate in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Production:
3-NITRO-THIOBENZAMIDE is employed as a component in the production of agrochemicals, playing a role in the development of products designed to enhance crop protection and yield.
Used in Dye Manufacturing:
3-NITRO-THIOBENZAMIDE is also used in the manufacturing of dyes, where its chemical properties contribute to the creation of various colorants for different applications.

InChI:InChI=1/C7H6N2O2S/c8-7(12)5-2-1-3-6(4-5)9(10)11/h1-4H,(H2,8,12)

Upstream product

• 507-09-5 thioacetic acid 
• 619-24-9 3-nitrobenzonitrile 
• 879905-34-7 3-nitro-benzaldehyde imine 
• 121-92-6 3-nitrobenzoic acid 
• 99-61-6 3-nitro-benzaldehyde 
• 619-23-8 3-Nitrobenzyl chloride 
• 645-09-0 3-nitrobenzamide 
• 66907-51-5 3-nitrobenzyl thiocyanate 

Downstream Products

• 76659-40-0 2-(3-nitro-phenyl)-thiazolo[4,5-b]quinoxaline 
• 250258-61-8 2-{2-[2-(3-nitro-phenyl)-thiazol-4-yl]-ethyl}-isoindole-1,3-dione 
• 121262-07-5 2-(3-nitrophenyl)thiazole-4-carboxylic acid ethyl ester 
• 96159-88-5 2-(3-nitrophenyl)-4,5-dihydro-1,3-thiazole 
• 619-24-9 3-nitrobenzonitrile 
• 29942-10-7 6-[2-(3-nitro-phenyl)-thiazol-4-yl]-benzothiazole 
• 29947-37-3 2-[2-(3-nitro-phenyl)-thiazol-4-yl]-benzothiazole 
• 4115-15-5 3,5-diphenyl-[1,2,4]thiadiazole 
• 106537-77-3 3,5-bis(3-nitrophenyl)-1,2,4-thiadiazole 
• 1415820-01-7 methyl 4-(2-(3-nitrophenyl)thiazol-4-yl)-1H-pyrrole-2-carboxylate 
• 1415819-69-0 C₂₃H₂₆N₄O₂S 
• 1415820-40-4 C₂₁H₂₁ClN₄O₂S 
• 1415820-39-1 (4-(2-(3-aminophenyl)thiazol-4-yl)-1H-pyrrol-2-yl)(piperidin-1-yl)methanone 
• 1415820-38-0 (4-(2-(3-nitrophenyl)thiazol-4-yl)-1H-pyrrol-2-yl)(piperidin-1-yl)methanone 

Relevant academic research and scientific papers

Mo (CO)6-assisted Pd-supported magnetic graphene oxide-catalyzed carbonylation-cyclization as an efficient way for the synthesis of 4(3H)-quinazolinones

In this paper, a novel catalyst is introduced based on the immobilization of palladium on modified magnetic graphene oxide nanoparticles. The catalyst is characterized by several methods, including transmission electron microscopy, scanning electron microscopy, X-ray fluorescence, vibrating-sample magnetometer, Fourier transform-infrared and dynamic light scattering (DLS) analysis. The activity of the catalyst was investigated in the synthesis of 4(3H)-quinazolinones via Pd-catalyzed carbonylation-cyclization of N-(2-bromoaryl) benzimidamides by Mo (CO)6. The Mo (CO)6 is used as a carbon monoxide source for performing the reaction under mild conditions. The catalyst showed good reusability, and no change in activity was observed after 10?cycles of recovery.

Metal-free, one-pot oxidative conversion of aldehydes to primary thioamides in aqueous media

One-pot tandem reactions of a variety of aldehydes with aqueous ammonia, molecular iodine, and O,O-diethyl dithiophosphoric acid readily afford the corresponding primary thioamides. This is an inexpensive, practical, and metal-free way of accessing various thioamides from aldehydes in aqueous media. The pure products are obtained simply by filtration followed by successive washing with aqueous sodium thiosulfate and water. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]

Crystal landscape of primary aromatic thioamides

The crystal landscape of a series of primary aromatic thioamides is described, displaying similar characteristic intermolecular hydrogen-bonding interactions in the solid state to those observed in their widely studied amide analogues, including R22(8) dimers and C(4) chains. In a number of cases, high Z′ values were observed in the structures. On the basis of the observed solid-state features, the thioamide functional group, which is a strong hydrogen-bond donor and moderate acceptor, offers considerable potential as a key moiety for crystal engineering.

Sulfonic acid functionalized nano Γ-Al 2O 3: A new, efficient, and reusable catalyst for synthesis of thioamides

Sulfonic acid functionalized nano γ-Al2O3 is easily prepared by the reaction of nano γ-Al2O3 with 1,3-propane sulfone. This reagent can be used as an eficient catalyst for the synthesis of thioamides. This new method consistently has the advantages of excellent yields and short reaction times. Further, the catalyst can be recovered for several times.

Nano n -propylsulfonated magnetic γ-Fe2O3 as an efficient and reusable catalyst for the synthesis of thioamides

One-pot three-component reactions of aldehydes, amines, and sulfur are carried out in the presence of nano n-propylsulfonated magnetic γ-Fe2O3 as a catalyst for the synthesis of biologically interesting thioamide derivatives. The value of this catalytic method lies in its mild reaction catalyst and conditions, good yields, and ease of handling.

3H-1,2,4-Dithiazol-3-one compounds as novel potential affordable antitubercular agents

Small molecules with oxathiazol-2-one moiety were recently reported as potent inhibitors of Mycobacterium bovis var. bacilli Calmette-Guérin (BCG), among which HT1171 was the most potent and selective proteasome inhibitor. Herein we synthesized a series of novel compounds by bioisosteric replacement of the oxathiazol-2-one ring with 3H-1,2,4-dithiazol-3-one, and also fifteen 1,3,4-oxathiazol-2-one molecules in order for potency comparison and structure-activity relationship elucidation since their antibacterial effects on the virulent strains were not evaluated before. All the compounds were assessed for antitubercular activities on the virulent H37Rv strain by a serial dilution method. Among the tested compounds, 3H-1,2,4-dithiazol-3-one compound 4n was found to be the most active with a lowest MIC90 value of 1 μg/mL. Furthermore, the cytotoxicities of all the compounds against normal human liver cell line L02 were determined by an MTT method. Compound 4n displayed a lower inhibitory ratio than HT1171 at the concentration of 100 μM, indicating its better safety profile.

Sulfated tungstate: An efficient catalyst for synthesis of thioamides via Kindler reaction

New application of sulfated tungstate, a mildly acidic solid inorganic acid, as reusable heterogeneous catalyst for efficient Kindler reaction, a three component reactions of aldehydes, amines and sulfur, for synthesis of thioamides is discussed.

A thiophosphoryl chloride assisted transformation of arylaldoximes to thioamides

Primary benzothioamides were accessed from benzaldoximes (benzaldehyde oximes) via benzonitriles in a sequential tandem approach utilizing thiophosphoryl chloride as a dehydrating and thionating agent. Georg Thieme Verlag Stuttgart New York.

COMPOSITIONS AND METHODS FOR MODULATING A KINASE

The invention relates to compounds and methods for modulating one or more components of a kinase signaling cascade

Design, synthesis and biological activity evaluation of 2,5-diphenyl-1,3,4-oxadiazole derivatives as novel inhibitors of fructose-1,6-bisphosphatase

Fructose-1,6-bisphosphatase (FBPase), an important gluconeogenic enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. The effort to discover new FBPase inhibitors was carried out by high-throughput screening (HTS) of a library of 56,000 lead-like compounds, and a 2,5-diphenyl-1,3,4-oxadiazole (3a, IC50 = 15.45 μM) which bearing no phosphate group was identified as a potential FBPase inhibitor for the first time. Structure-activity-relationship (SAR) research of a series of analogues obtained by modifying the substituent groups and replacing the 1,3,4-oxadiazole with several other heterocycles disclosed the key structure and substituent groups related to the binding with FBPase.