N-benzyl-N-(pyridin-2-yl)pyridin-2-amine

Base Information

• Chemical Name: N-benzyl-N-(pyridin-2-yl)pyridin-2-amine
• CAS No.: 26422-90-2
• Molecular Formula: C17H15N3
• Molecular Weight: 261.326
• DSSTox Substance ID: DTXSID90559411
• Nikkaji Number: J1.284.640A
• Wikidata: Q82442119
• Mol file: 26422-90-2.mol

Synonyms:benzyldi(2-pyridyl)amine;N-benzyl-N-(pyridin-2-yl)pyridin-2-amine;26422-90-2;N-benzyldi(2-pyridyl)amine;SCHEMBL5609247;DTXSID90559411;ILSNYJBZMLHITI-UHFFFAOYSA-N;AKOS005605705;2-Pyridinamine, N-(phenylmethyl)-N-(2-pyridinyl)-

Chemical Property of N-benzyl-N-(pyridin-2-yl)pyridin-2-amine

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 261.126597491
• Heavy Atom Count: 20
• Complexity: 257

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CN(C2=CC=CC=N2)C3=CC=CC=N3

Technology Process of N-benzyl-N-(pyridin-2-yl)pyridin-2-amine

There total 7 articles about N-benzyl-N-(pyridin-2-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-bromo-pyridine (109-04-6) + benzylamine (100-46-9) → N-benzyl-N-(pyridin-2-yl)pyridine-2-amine (26422-90-2)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 80 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.organomet.6b00895

Reference yield: 82.0%

di(pyridin-2-yl)amine (1202-34-2) + benzyl chloride (100-44-7) → N-benzyl-N-(pyridin-2-yl)pyridine-2-amine (26422-90-2)

Guidance literature:

di(pyridin-2-yl)amine; With potassium hydroxide; In dimethyl sulfoxide; for 0.75h;

benzyl chloride; In dimethyl sulfoxide; at 20 ℃; for 20h;

DOI:10.1039/c4dt00537f

Reference yield: 82.0%

2-[N-methyl-N-(pyridin-2-yl)amino]pyridine (123368-97-8) + benzyl chloride (100-44-7) → N-benzyl-N-(pyridin-2-yl)pyridine-2-amine (26422-90-2)

Guidance literature:

2-[N-methyl-N-(pyridin-2-yl)amino]pyridine; With potassium hydroxide; In dimethyl sulfoxide; for 0.75h;

benzyl chloride; In dimethyl sulfoxide; at 25 ℃; for 20h; Schlenk technique; Inert atmosphere;

DOI:10.1021/om5001293

upstream raw materials:

di(pyridin-2-yl)amine

benzyl chloride

2-chloropyridine

benzylamine

Downstream raw materials:

{bis(benzyldi-2-pyridylamine)-η2,η'2-(s-trans-isoprene)dicopper(I)} bistrifluoromethanesulfonate

Pd((2,2'-dipyridyl)benzilamine)Cl₂

[Ni(μ-Cl){2,2′-dipyridyl-N-benzylamine}Cl]2

Pd^(II)Me(2,2′-dipyridyl-N-benzylamine)Cl