2,3-dimethoxy-5,12b-dihydroisoindolo[1,2-a]isoquinolin-8(6H)-one

Base Information

Chemical Name:2,3-dimethoxy-5,12b-dihydroisoindolo[1,2-a]isoquinolin-8(6H)-one
CAS No.:26477-10-1
Molecular Formula:C18H17NO3
Molecular Weight:295.338
Hs Code.:
European Community (EC) Number:668-103-9
DSSTox Substance ID:DTXSID20405114
Nikkaji Number:J769.488A

Synonyms:2,3-dimethoxy-5,12b-dihydroisoindolo[1,2-a]isoquinolin-8(6H)-one;26477-10-1;DTXSID20405114;AKOS024324335;Isoindolo[1,2-a]isoquinolin-8(6H)-one, 5,12b-dihydro-2,3-dimethoxy-;2,3-dimethoxy-6,12b-dihydro-5H-isoquinolino[2,1-b]isoindol-8-one

Suppliers and Price of 2,3-dimethoxy-5,12b-dihydroisoindolo[1,2-a]isoquinolin-8(6H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,3-dimethoxy-5,12b-dihydroisoindolo[1,2-a]isoquinolin-8(6H)-one

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:295.12084340
Heavy Atom Count:22
Complexity:440

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C3C4=CC=CC=C4C(=O)N3CCC2=C1)OC

Technology Process of 2,3-dimethoxy-5,12b-dihydroisoindolo[1,2-a]isoquinolin-8(6H)-one

There total 6 articles about 2,3-dimethoxy-5,12b-dihydroisoindolo[1,2-a]isoquinolin-8(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 4122-56-9
methyl o-formylbenzoate

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 26477-10-1
2,3-dimethoxy-5,6-dihydroisoindolyl[1,2-a]isoquinolin-8(12bH)-one

: C₁₉H₂₁NO₄

Guidance literature:: With trifluoroacetic acid; In chloroform; at 60 ℃; for 5h; Reagent/catalyst; Concentration; Solvent;
DOI:10.1016/j.tet.2021.132280

Reference yield: 39.0%

: 119072-54-7,2769-71-3
2,6-dimethylphenyl isonitrile

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 119-67-5
o-carboxybenzaldehyde

: 26477-10-1
2,3-dimethoxy-5,6-dihydroisoindolyl[1,2-a]isoquinolin-8(12bH)-one

: 2-(3,4-dimethoxyphenylethyl)-N-(2,6-dimethylphenyl)-3-oxoisoindoline-1-carboxamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 20 ℃; for 0.25h;
DOI:10.1016/j.tetlet.2018.08.063

Reference yield:

: 493-49-2
6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one

: 26477-10-1
2,3-dimethoxy-5,6-dihydroisoindolyl[1,2-a]isoquinolin-8(12bH)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C

1.2: 80 percent / tetrahydrofuran; hexane / 2.17 h / -78 - 20 °C

2.1: 62 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 20 °C

3.1: 92 percent / triethylsilyl hydride; TFA / CH₂Cl₂ / 2 h / 20 °C

With triethylsilane; n-butyllithium; tert.-butyl lithium; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; pentane;
DOI:10.1002/ejoc.200500312