Technology Process of 1H-Pyrrole-2,5-dicarboxylic acid,
3-[4,5-dimethoxy-2-(methoxymethoxy)phenyl]-4-(3,4-dimethoxyphenyl)-,
dimethyl ester
There total 7 articles about 1H-Pyrrole-2,5-dicarboxylic acid,
3-[4,5-dimethoxy-2-(methoxymethoxy)phenyl]-4-(3,4-dimethoxyphenyl)-,
dimethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
acetic acid; zinc;
at 25 ℃;
for 18.5h;
DOI:10.1021/jo9916535
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 87 percent / PdCl2(PPh3)2; CuI; Et3N / dimethylformamide / 4 h / 75 °C
2: Na2HPO4; m-CPBA / CH2Cl2 / 18 h / 25 °C
3: aq. KOH / methanol / 1.5 h / 25 °C
4: 67 percent / i-Pr2NEt / CH2Cl2 / 18 h / 25 °C
5: 92 percent / 1,3,5-trimethyl-benzene / 48 h / 140 °C
6: 62 percent / Zn; HOAc / 18.5 h / 25 °C
With
bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; disodium hydrogenphosphate; copper(l) iodide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; zinc;
In
methanol; dichloromethane; N,N-dimethyl-formamide; 1,3,5-trimethyl-benzene;
1: Condensation / 2: Baeyer-Villiger oxidation / 3: Hydrolysis / 4: Alkylation / 5: Diels-Alder reaction / 6: reductive ring contraction;
DOI:10.1021/jo9916535
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 87 percent / PdCl2(PPh3)2; CuI; Et3N / dimethylformamide / 4 h / 75 °C
2: Na2HPO4; m-CPBA / CH2Cl2 / 18 h / 25 °C
3: aq. KOH / methanol / 1.5 h / 25 °C
4: 67 percent / i-Pr2NEt / CH2Cl2 / 18 h / 25 °C
5: 92 percent / 1,3,5-trimethyl-benzene / 48 h / 140 °C
6: 62 percent / Zn; HOAc / 18.5 h / 25 °C
With
bis-triphenylphosphine-palladium(II) chloride; potassium hydroxide; disodium hydrogenphosphate; copper(l) iodide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; zinc;
In
methanol; dichloromethane; N,N-dimethyl-formamide; 1,3,5-trimethyl-benzene;
1: Condensation / 2: Baeyer-Villiger oxidation / 3: Hydrolysis / 4: Alkylation / 5: Diels-Alder reaction / 6: reductive ring contraction;
DOI:10.1021/jo9916535
