PHENYL ACRIDINE-9-CARBOXYLATE

Base Information

• Chemical Name: PHENYL ACRIDINE-9-CARBOXYLATE
• CAS No.: 109392-90-7
• Molecular Formula: C20H13 N O2
• Molecular Weight: 299.329
• Hs Code.: 2933990090
• Mol file: 109392-90-7.mol

Synonyms:Phenyl9-acridinecarboxylate

Chemical Property of PHENYL ACRIDINE-9-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 1.7E-10mmHg at 25°C
• Melting Point: 188-192 °C
• Refractive Index: 1.5180 (estimate)
• Boiling Point: 509.4°Cat760mmHg
• PKA: 2.63±0.10(Predicted)
• Flash Point: 261.9°C
• PSA: 39.19000
• Density: 1.277g/cm³
• LogP: 4.60720
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Phenylacridine-9-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PHENYL ACRIDINE-9-CARBOXYLATE

There total 4 articles about PHENYL ACRIDINE-9-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

acridine-9-carbonyl chloride hydrochloride (5132-80-9) + phenol (108-95-2,27073-41-2) → phenyl acridine-9-carboxylate (109392-90-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 18h;

DOI:10.1021/ja00251a024

Reference yield:

9-acridinecarbonyl chloride (66074-67-7) + phenol (108-95-2,27073-41-2) → phenyl acridine-9-carboxylate (109392-90-7)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃;

DOI:10.1016/j.saa.2007.10.045

Reference yield:

acridine-9-carboxylic acid (5336-90-3) → phenyl acridine-9-carboxylate (109392-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / thionyl chloride / 6 h / Heating

2: 80 percent / potassium tert-butoxide / tetrahydrofuran / 18 h

With thionyl chloride; potassium tert-butylate; In tetrahydrofuran;

DOI:10.1021/ja00251a024

upstream raw materials:

acridine-9-carbonyl chloride hydrochloride

phenol

acridine-9-carboxylic acid

9-acridinecarbonyl chloride

Downstream raw materials:

9-phenoxycarbonyl-10-carboxyethylacridinium bromide

phenyl 10-methyl-10λ⁴-acridine-9-carboxylate trifluoromethanesulfonate

10-methyl-9, 10-dihydro-9-acridinone

phenol

Refernces

• 1、 Krzyminski, Karol,Ozog, Agnieszka,Malecha, Piotr,Roshal, Alexander D.,Wroblewska, Agnieszka,Zadykowicz, Beata,Blazejowski, Jerzy. "Chemiluminogenic features of 10-Methyl-9-(phenoxycarbonyl)acridinium Trifluoromethanesulfonates alkyl substituted at the benzene ring in aqueous media". experimental part. p. 1072 - 1085. Retrieved 2011/04/16.
• 2、 Zadykowicz,Ozóg,Krzymiński. "Vibrational spectra of phenyl acridine-9-carboxylates and their 10-methylated cations: A theoretical and experimental study". experimental part. p. 1546 - 1551. Retrieved 2010/06/21.