N-(1-phenylpropyl)acetamide

Base Information

• Chemical Name: N-(1-phenylpropyl)acetamide
• CAS No.: 2698-79-5
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.246
• DSSTox Substance ID: DTXSID40373023
• Nikkaji Number: J1.252.569I
• Mol file: 2698-79-5.mol

Synonyms:N-(1-phenylpropyl)acetamide;2698-79-5;Acetamide, N-(1-phenylpropyl)-;SCHEMBL186416;DTXSID40373023;HMS1672E04;STL256687;AKOS003558990;F8880-7968

Chemical Property of N-(1-phenylpropyl)acetamide

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 162

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C1=CC=CC=C1)NC(=O)C

Technology Process of N-(1-phenylpropyl)acetamide

There total 49 articles about N-(1-phenylpropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-acetyl-1-phenylpropenamine (2890-85-9) → (R)-N-(1-phenylpropyl)acetamide (2698-79-5,20306-86-9,57680-92-9)

Guidance literature:

With (S,S)-ethane-1,2-bis(4-phosphacycloheptabinaphthalene); hydrogen; [rhodium(I)(norborna-2,5-diene)2]SbF₆; In methanol; at 20 ℃; for 24h; under 2068.59 Torr;

DOI:10.1016/S0040-4039(02)00877-8

Reference yield: 95.0%

1-Phenyl-1-propanol (93-54-9) + acetonitrile (75-05-8,26809-02-9) → N-(1-phenylpropyl)acetamide (20306-86-9,57680-92-9,2698-79-5)

Guidance literature:

With HClO4-functionalized silica-coated magnetic nanoparticles [γ-Fe2O3@SiO2-HClO4]; at 20 ℃; for 4h; Neat (no solvent);

DOI:10.1016/j.apcata.2010.06.014

Reference yield: 90.0%

1-phenylpropylamine (2941-20-0) + ethyl acetate (141-78-6) → (R)-N-(1-phenylpropyl)acetamide (2698-79-5,20306-86-9,57680-92-9)

Guidance literature:

With 4 A molecular sieve; Novozym-435; aluminum oxyhydroxide; palladium; In toluene; at 70 ℃; for 72h;

DOI:10.1021/ol070130d

upstream raw materials:

vinyl acetate

1-phenylpropylamine

triethylamine-1-(2-naphthylethyl)borane

cyclopropylbenzene

Downstream raw materials:

1-phenylpropylamine