Carbamic acid, [(1S)-2-[4-(1,1-dimethylethoxy)phenyl]-1-[[[[(2,5-dioxo-1-pyrrolidinyl)oxy] carbonyl]amino]methyl]ethyl]-, 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [(1S)-2-[4-(1,1-dimethylethoxy)phenyl]-1-[[[[(2,5-dioxo-1-pyrrolidinyl)oxy] carbonyl]amino]methyl]ethyl]-, 9H-fluoren-9-ylmethyl ester
• CAS No.: 270575-75-2
• Molecular Formula: C₃₃H₃₅N₃O₇
• Molecular Weight: 585.657
• Mol file: 270575-75-2.mol

Synonyms:

Chemical Property of Carbamic acid, [(1S)-2-[4-(1,1-dimethylethoxy)phenyl]-1-[[[[(2,5-dioxo-1-pyrrolidinyl)oxy] carbonyl]amino]methyl]ethyl]-, 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [(1S)-2-[4-(1,1-dimethylethoxy)phenyl]-1-[[[[(2,5-dioxo-1-pyrrolidinyl)oxy] carbonyl]amino]methyl]ethyl]-, 9H-fluoren-9-ylmethyl ester

There total 4 articles about Carbamic acid, [(1S)-2-[4-(1,1-dimethylethoxy)phenyl]-1-[[[[(2,5-dioxo-1-pyrrolidinyl)oxy] carbonyl]amino]methyl]ethyl]-, 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + [2-(4-tert-butoxy-phenyl)-1-isocyanatomethyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester → succinimidyl {(2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-[4-(tert-botoxy)phenyl]propyl}carbamate (270575-75-2)

Guidance literature:

In pyridine; at 65 ℃; for 0.0833333h;

DOI:10.1016/S0040-4039(99)02353-9

Reference yield:

(S)-3-(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)-4-<4-(tert-butoxy)phenyl>butanoic acid (219967-69-8) → succinimidyl {(2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-[4-(tert-botoxy)phenyl]propyl}carbamate (270575-75-2)

Guidance literature:

Multi-step reaction with 4 steps

1: N-methylmorpholine / tetrahydrofuran / 0.33 h / -20 °C

2: aq. NaN₃ / tetrahydrofuran / 0.08 h / -10 °C

3: toluene / 0.17 h / 65 °C

4: 2.28 g / pyridine / toluene / 0.08 h / 65 °C

With 4-methyl-morpholine; pyridine; sodium azide; In tetrahydrofuran; toluene; 3: Curtius reaarangement;

DOI:10.1002/1522-2675(200211)85:11<3692::AID-HLCA3692>3.0.CO;2-W

Reference yield:

C32H35NO7 → succinimidyl {(2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-[4-(tert-botoxy)phenyl]propyl}carbamate (270575-75-2)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaN₃ / tetrahydrofuran / 0.08 h / -10 °C

2: toluene / 0.17 h / 65 °C

3: 2.28 g / pyridine / toluene / 0.08 h / 65 °C

With pyridine; sodium azide; In tetrahydrofuran; toluene; 2: Curtius reaarangement;

DOI:10.1002/1522-2675(200211)85:11<3692::AID-HLCA3692>3.0.CO;2-W

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

(S)-3-(<<(9H-fluoren-9-yl)methoxy>carbonyl>amino)-4-<4-(tert-butoxy)phenyl>butanoic acid

[1-azidocarbonylmethyl-2-(4-tert-butoxy-phenyl)-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester