ethyl 5-(3,4-dimethoxyphenyl)-2-[(7-methoxy-2-phenyl-1H-indol-3-yl)methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

Base Information

Chemical Name:ethyl 5-(3,4-dimethoxyphenyl)-2-[(7-methoxy-2-phenyl-1H-indol-3-yl)methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS No.:6468-44-6
Molecular Formula:C16H12 O3
Molecular Weight:252.269
Hs Code.:
DSSTox Substance ID:DTXSID30412859

ethyl 5-(3,4-dimethoxyphenyl)-2-[(7-methoxy-2-phenyl-1H-indol-3-yl)methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

Synonyms:6468-44-6;AC1NRPA3;Oprea1_135185;DTXSID30412859

Suppliers and Price of ethyl 5-(3,4-dimethoxyphenyl)-2-[(7-methoxy-2-phenyl-1H-indol-3-yl)methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of ethyl 5-(3,4-dimethoxyphenyl)-2-[(7-methoxy-2-phenyl-1H-indol-3-yl)methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

Chemical Property:

Vapor Pressure:1.96E-24mmHg at 25°C
Boiling Point:782.4°Cat760mmHg
Flash Point:427°C
Density:1.32g/cm³
XLogP3:6.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:9
Exact Mass:609.19335689
Heavy Atom Count:44
Complexity:1180

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C2N(C1C3=CC(=C(C=C3)OC)OC)C(=O)C(=CC4=C(NC5=C4C=CC=C5OC)C6=CC=CC=C6)S2)C

Technology Process of ethyl 5-(3,4-dimethoxyphenyl)-2-[(7-methoxy-2-phenyl-1H-indol-3-yl)methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

There total 4 articles about ethyl 5-(3,4-dimethoxyphenyl)-2-[(7-methoxy-2-phenyl-1H-indol-3-yl)methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 700-44-7
6-methoxysalicylaldehyde

: 1333483-14-9
N-methyll-N-(phenylethylnyl)methanesulfonamide

: 6468-44-6
5-methoxy-3-phenyl-2H-chromen-2-one

Guidance literature:: With zinc dibromide; In toluene; at 120 ℃; for 2h;
DOI:10.1021/acs.orglett.9b01181

Reference yield: 88.0%

: 591-50-4
iodobenzene

: 81017-29-0
5-methoxy-2-oxo-2H-1-benzopyran-3-carboxylic acid

: 6468-44-6
5-methoxy-3-phenyl-2H-chromen-2-one

Guidance literature:: With silver carbonate; palladium dichloride; In dimethyl sulfoxide; at 120 ℃; for 5h;
DOI:10.1021/jo302778d

Reference yield:

: 932-87-6
1-Bromo-2-phenylacetylene

: 6468-44-6
5-methoxy-3-phenyl-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline; potassium carbonate / toluene / 80 °C / Inert atmosphere

2: zinc dibromide / toluene / 2 h / 120 °C

With 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; zinc dibromide; In toluene;
DOI:10.1021/acs.orglett.9b01181