4-FLUOROBENZYL THIOCYANATE

Base Information

• Chemical Name: 4-FLUOROBENZYL THIOCYANATE
• CAS No.: 2740-87-6
• Molecular Formula: C8H6FNS
• Molecular Weight: 167.207
• Mol file: 2740-87-6.mol

Synonyms:p-fluorobenzyl thiocyanate;p-Fluorobenzyl methyl ether;1-fluoro-4-methoxymethyl-benzene;

Chemical Property of 4-FLUOROBENZYL THIOCYANATE

Chemical Property:

• PSA: 49.09000
• LogP: 2.53998

Purity/Quality:

98%min ^*data from raw suppliers

4-Fluorobenzyl thiocyanate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUOROBENZYL THIOCYANATE

There total 4 articles about 4-FLUOROBENZYL THIOCYANATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-fluorobenzylic alcohol (459-56-3) + ammonium thiocyanate (1147550-11-5) → p-fluorobenzyl thiocyanate (2740-87-6)

Guidance literature:

With fluorosulfonyl fluoride; sodium carbonate; In ethyl acetate; at 20 ℃; for 5h;

DOI:10.1055/s-0040-1707151

Reference yield: 75.0%

4-fluorobenzylic alcohol (459-56-3) + sodium thiocyanide (540-72-7) → p-fluorobenzyl thiocyanate (2740-87-6)

Guidance literature:

With triphenyl phosphite; 2,6-lutidinium perchlorate; In dichloromethane; for 9.83333h; Ambient temperature; electrolysis;

DOI:10.1248/cpb.38.1389

Reference yield:

sodium thiocyanide (540-72-7) + 4-Fluorobenzyl bromide (459-46-1) → p-fluorobenzyl thiocyanate (2740-87-6)

Guidance literature:

In N,N-dimethyl acetamide; at 25 ℃; for 1h;

DOI:10.1016/j.tet.2017.08.048

upstream raw materials:

4-fluorobenzylic alcohol

sodium thiocyanide

4-Fluorobenzyl bromide

ammonium thiocyanate

Downstream raw materials:

(4-fluorophenyl)methanethiol

4-fluorobenzyl 1-propynyl sulfone

4-fluorobenzyl 1-propynyl sulfide

4-fluorobenzylisothiocyanate