4-fluorobenzyl 1-propynyl sulfone

Base Information

• Chemical Name: 4-fluorobenzyl 1-propynyl sulfone
• CAS No.: 1334032-96-0
• Molecular Formula: C₁₀H₉FO₂S
• Molecular Weight: 212.245
• Mol file: 1334032-96-0.mol

Synonyms:4-fluorobenzyl 1-propynyl sulfone

Chemical Property of 4-fluorobenzyl 1-propynyl sulfone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-fluorobenzyl 1-propynyl sulfone

There total 2 articles about 4-fluorobenzyl 1-propynyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluorobenzyl 1-propynyl sulfide (1334032-51-7) → 4-fluorobenzyl 1-propynyl sulfone (1334032-96-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 6 ℃; Inert atmosphere;

DOI:10.1021/ol202196y

Reference yield:

p-fluorobenzyl thiocyanate (2740-87-6) → 4-fluorobenzyl 1-propynyl sulfone (1334032-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 6 °C / Inert atmosphere

With n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/ol202196y

upstream raw materials:

4-fluorobenzyl 1-propynyl sulfide

p-fluorobenzyl thiocyanate