5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(4-fluorophenyl)acetyl]amino]-8-oxo-, (6R,7R)-

Base Information

• Chemical Name: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(4-fluorophenyl)acetyl]amino]-8-oxo-, (6R,7R)-
• CAS No.: 28031-33-6
• Molecular Formula: C₁₈H₁₇FN₂O₆S
• Molecular Weight: 408.407
• Mol file: 28031-33-6.mol

Synonyms:

Chemical Property of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(4-fluorophenyl)acetyl]amino]-8-oxo-, (6R,7R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(4-fluorophenyl)acetyl]amino]-8-oxo-, (6R,7R)-

There total 2 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(4-fluorophenyl)acetyl]amino]-8-oxo-, (6R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ (6R,7R)-3-(acetoxymethyl)-7-(2-(4-fluorophenyl)-acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (28031-33-6)

Guidance literature:

Reference yield: 41.0%

7-Aminocephalosporanic acid (957-68-6) + 4-Fluorophenylacetyl chloride (459-04-1) → (6R,7R)-3-(acetoxymethyl)-7-(2-(4-fluorophenyl)-acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (28031-33-6)

Guidance literature:

7-Aminocephalosporanic acid; 4-Fluorophenylacetyl chloride; In ethyl acetate; for 0.5h; Inert atmosphere; Reflux;

With aniline; In ethyl acetate; at 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.8b01923

upstream raw materials:

7-Aminocephalosporanic acid

4-Fluorophenylacetyl chloride