459-04-1

Basic information

• Product Name: 4-Fluorophenylacetyl chloride
• Synonyms: 4-FLUOROBENZENEACETYL CHLORIDE;2-(4-Fluorophenyl)acetyl chloride;4-fluorobenzencacetyl chloride;4-Fluorophenacylchloride,alpha-Chloro-4-fluoroacetophenone;4-FLUOROPHENYLACETYL CHLORIDE 99%;4-Fluorophenylacetyl chloride ,98%;4-fluorophenylacethyl chloride;Of fluorobenzene chloride
• CAS NO: 459-04-1
• Molecular Formula: C₈H₆ClFO
• Molecular Weight: 172.58
• EINECS: -0
• Product Categories: Fluorobenzene;Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 459-04-1.mol
• Article Data: 101

Chemical Properties

• Melting Point: 47-48
• Boiling Point: 60 °C (8 mmHg)
• Flash Point: 107 °C
• Appearance: Clear yellow/Liquid
• Density: 1.259 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0884mmHg at 25°C
• Refractive Index: 1.511-1.513
• Storage Temp.: Store at RT.
• Solubility: Miscible with dichloromethane.
• Sensitive: Moisture Sensitive
• BRN: 972148
• CAS DataBase Reference: 4-Fluorophenylacetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluorophenylacetyl chloride(459-04-1)
• EPA Substance Registry System: 4-Fluorophenylacetyl chloride(459-04-1)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-29-14
• Safety Statements: 45-36/37/39-26-27
• RIDADR: 3265
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 459-04-1(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow liquid

Uses

Different sources of media describe the Uses of 459-04-1 differently. You can refer to the following data:
1. 4-Fluorophenylacetyl chloride is used as an acylating agent in organic synthesis. It is used to prepare monoacylated pyrazolidine by reacting with pyrazolidine. It is also used in the preparation of N-acyl isothiouronium chloride.
2. 4-Fluorophenylacetyl chloride may be used in the preparation of bicyclic pyrazolones and dihydropyrrol-2-ones.

InChI:InChI=1/C8H6ClFO/c9-8(11)5-6-1-3-7(10)4-2-6/h1-4H,5H2

Upstream product

• 405-50-5 p-Fluorophenylacetic acid 
• 405-51-6 4-fluorophenyl acetate 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 79-37-8 oxalyl dichloride 
• 459-46-1 4-Fluorobenzyl bromide 
• 459-22-3 4-fluorophenylacetonitrile 
• 352-32-9 p-fluorotoluene 

Downstream Products

• 2251-23-2 (4-fluoro-phenyl)-acetic acid-(2-piperidino-ethyl ester) 
• 366-68-7 4,4'-difluorodeoxybenzoin 
• 347-91-1 2-(4-fluorophenyl)-1-phenylethanone 
• 243640-37-1 4-[1-hydroxy-1-(2,3-dimethoxyphenyl)methyl]-N-2-(4-fluorophen-1-oxo-ethyl)piperidine 
• 587-88-2 ethyl 2-(4-fluorophenyl)acetate 
• 189626-04-8 4-(4-fluorophenyl)-2-methylbuta-2,3-dienoic acid ethyl ester 
• 856259-08-0 N-benzyl-N-[2-(4-benzyloxy-3-methoxy-phenyl)-ethyl]-2-(4-fluoro-phenyl)-acetamide 
• 864960-85-0 C₁₆H₁₆FNO 
• 607721-47-1 (4-fluorophenyl)-acetic acid N-methyl-hydrazide 
• 218591-03-8 methyl (E)-4-(4-fluorophenyl)-3-methoxycarbonylbut-3-enoate 

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