459-04-1

Usage

Uses

Used in Organic Synthesis:
4-Fluorophenylacetyl chloride is used as an acylating agent for the preparation of various organic compounds. Its ability to react with different substrates makes it a versatile tool in the synthesis of complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Fluorophenylacetyl chloride is used to prepare monoacylated pyrazolidine by reacting with pyrazolidine. 4-Fluorophenylacetyl chloride has potential applications in the development of new drugs and therapeutic agents.
Used in Chemical Research:
4-Fluorophenylacetyl chloride is also utilized in the preparation of N-acyl isothiouronium chloride, which is an important intermediate in the synthesis of various chemical compounds. This application highlights the compound's role in advancing chemical research and development.
Used in the Synthesis of Bicyclic Pyrazolones and Dihydropyrrol-2-ones:
Furthermore, 4-Fluorophenylacetyl chloride may be employed in the synthesis of bicyclic pyrazolones and dihydropyrrol-2-ones. These compounds have potential applications in various fields, including pharmaceuticals, materials science, and agrochemicals, due to their unique chemical properties and structures.

InChI:InChI=1/C8H6ClFO/c9-8(11)5-6-1-3-7(10)4-2-6/h1-4H,5H2

Upstream product

• 405-50-5 p-Fluorophenylacetic acid 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 79-37-8 oxalyl dichloride 
• 405-51-6 4-fluorophenyl acetate 
• 459-22-3 4-fluorophenylacetonitrile 
• 352-32-9 p-fluorotoluene 
• 459-46-1 4-Fluorobenzyl bromide 

Downstream Products

• 366-68-7 4,4'-difluorodeoxybenzoin 
• 159976-49-5 7-amino-8-(4-fluorophenylacetylamino)-2-phenyl-1,2,4-triazolo<1,5-c>pyrimidine 
• 159976-61-1 4-amino-6-benzoylhydrazino-5-(4-fluorophenylacetylamino)pyrimidine 
• 159976-51-9 7-amino-2-(2-fluorophenyl)-8-(4-fluorophenylacetylamino)-1,2,4-triazolo<1,5-c>pyrimidine 
• 159976-63-3 4-amino-6-(2-fluorobenzoylhydrazino)-5-(4-fluorophenylacetylamino)pyrimidine 
• 87600-57-5 [2-(4-Fluoro-phenyl)-acetyl]-phosphonic acid dimethyl ester 
• 587-88-2 ethyl 2-(4-fluorophenyl)acetate 
• 218591-03-8 methyl (E)-4-(4-fluorophenyl)-3-methoxycarbonylbut-3-enoate 
• 762297-72-3 (4S)-3-[(4-fluorophenyl)acetyl]-4-isopropyl-1,3-oxazolidin-2-one 
• 762297-73-4 (4R)-3-[(4-fluorophenyl)acetyl]-4-isopropyl-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

Vibrational spectroscopic studies and computational study of 4-fluoro-N-(2′-hydroxy-4′-nitrophenyl)phenylacetamide

Fourier-transform infrared (FT-IR) and FT-Raman spectra of 4-fluoro-N-(2′-hydroxy-4′-nitrophenyl)phenylacetamide were recorded and analyzed. A surface-enhanced Raman scattering (SERS) spectrum was recorded in silver colloid. The vibrational wavenumbers an

N-monoarylacetothioureas as potent urease inhibitors: synthesis, SAR, and biological evaluation

A urease inhibitor with good in vivo profile is considered as an alternative agent for treating infections caused by urease-producing bacteria such as Helicobacter pylori. Here, we report a series of N-monosubstituted thioureas, which act as effective urease inhibitors with very low cytotoxicity. One compound (b19) was evaluated in detail and shows promising features for further development as an agent to treat H. pylori caused diseases. Excellent values for the inhibition of b19 against both extracted urease and urease in intact cell were observed, which shows IC50 values of 0.16 ± 0.05 and 3.86 ± 0.10 μM, being 170- and 44-fold more potent than the clinically used drug AHA, respectively. Docking simulations suggested that the monosubstituted thiourea moiety penetrates urea binding site. In addition, b19 is a rapid and reversible urease inhibitor, and displays nM affinity to urease with very slow dissociation (koff=1.60 × 10?3 s?1) from the catalytic domain.

Novel quinoline derivative inhibitor

The invention provides a novel quinoline derivative inhibitor, which has a structure represented by the following general formula (I). According to the invention, the compound provided by the invention can selectively inhibit tyrosine kinase TAM family/an

Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines

The asymmetric formal hydroamination of enamines using a CuH catalyst is reported. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of molecules bearing a 1,2-diamine motif.

Direct meta-C?H Perfluoroalkenylation of Arenes Enabled by a Cleavable Pyrimidine-Based Template

The development of efficient and mild methods for the synthesis of organofluorine compounds is of foremost interest in various fields of chemistry. A direct pyrimidine-based selective meta-C?H perfluoroalkenylation of arenes involving several commercially

TAM family kinase and/or CSF1R kinase inhibitor and application thereof

The invention provides a novel inhibitor compound shown in a general formula (I). The compound has good kinase inhibition activity and can be used for preventing and/or treating diseases mediated by abnormal expression of TAM family kinase and/or a ligand thereof. The compound can target CSF1R kinase and can be used for preventing and/or treating diseases mediated by abnormal expression of a TAM family kinase receptor and/or a CSF1R kinase receptor and/or ligands thereof.

A O - phenylacetylamino - (4 - trifluoromethyl) salicylic amide compound and use thereof

The invention discloses an O-phenylacetyl-(4-trifluoromethyl) salicylamide compound represented by formula (I), and applications thereof in preparing antitumor drugs.

Enantioselective 1,2-Anionotropic Rearrangement of Acylsilane through a Bisguanidinium Silicate Ion Pair

Highly enantioselective bisguanidinium-catalyzed tandem rearrangements of acylsilanes are reported. The acylsilanes were activated via an addition of fluoride on the silicon to form a penta-coordinate anionic silicate intermediate. The silicate then underwent alkyl or aryl group migration from the silicon atom to the neighboring carbonyl carbon atom (1,2-anionotropic rearrangement), followed by [1,2]-Brook rearrangement to provide the secondary alcohols in high yields with excellent enantioselectivities (up to 95% ee). The isolation of an α-silylcarbinol intermediate as well as DFT calculations revealed that the 1,2-anionotropic rearrangement occurred via a bisguanidinium silicate ion pair, which is the stereodetermining step. The chiral center formed is then retained without inversion through the subsequent [1,2]-Brook rearrangement. Crotyl acylsilanes were smoothly transformed into homoallylic linear crotyl alcohols with retention of E/Z geometry, and no branched alcohols were detected. This clearly suggested that the 1,2-anionotropic rearrangement occurred through a three-membered instead of a five-membered transition state.

Diastereoselective Electrophilic Trifluoromethylthiolation of Chiral Oxazolidinones: Access to Enantiopure α-SCF3 Alcohols

Lithium imide enolates featuring Evans’ chiral oxazolidinone auxiliary were involved in diastereoselective α-trifluoromethylthiolation with electrophilic SCF3 donors. Diastereopure products were isolated and converted to enantiopure α-SCF3 alcohols without racemisation. (Figure presented.).

Heterocyclic pyrrolizinone and indolizinones derived from natural lactam as potential antifungal agents

With the aim to develop highly potential active heterocyclic compounds, two series of multi-substituted pyrrolizinone and indolizinones derived from lactam were designed, synthesized and evaluated for their potential antifungal activities against six species of the plant pathogen fungi (Fusarium graminearum, Sclerotinia sclerotiorum, Phomopsis adianticola, Gloeosporium theae-sinensis, Alternaria tenuis Nees, Magnaporthe oryzae). The structure of all the newly molecules were confirmed by analytical spectroscopic data, including 1H NMR, 13C NMR and ESI-MS. According to the preliminary studies on bio-evaluation assay, some of the obtained compounds exhibited moderate and broad-spectrum activities against six fungi compared to the intermediates 6a, 6f and the hymexazol. Particularly, the inhibition rate of compounds 7l, 7m and 7t reached 69.25%, 74.76%, 65.38% against Phomopsis adianticola and Magnaporthe oryzae in vitro activity. Furthermore, compounds 7l and 7t displayed obviously inhibition activities against Phomopsis adianticola compared to the hymexazol. Consequently, compounds 7l and 7t with six-membered alkane ring could be used as new motifs for further investigation.