4-Piperidinecarboxylic acid, 1-[(2E)-3-[3-chloro-4-[(2-methoxyphenyl)thio]-2-(trifluoromethyl)phenyl]-1 -oxo-2-propenyl]-, ethyl ester

Base Information

• Chemical Name: 4-Piperidinecarboxylic acid, 1-[(2E)-3-[3-chloro-4-[(2-methoxyphenyl)thio]-2-(trifluoromethyl)phenyl]-1 -oxo-2-propenyl]-, ethyl ester
• CAS No.: 280752-12-7
• Molecular Formula: C25H25ClF3NO4S
• Molecular Weight: 527.992
• Mol file: 280752-12-7.mol

Synonyms:

Chemical Property of 4-Piperidinecarboxylic acid, 1-[(2E)-3-[3-chloro-4-[(2-methoxyphenyl)thio]-2-(trifluoromethyl)phenyl]-1 -oxo-2-propenyl]-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Piperidinecarboxylic acid, 1-[(2E)-3-[3-chloro-4-[(2-methoxyphenyl)thio]-2-(trifluoromethyl)phenyl]-1 -oxo-2-propenyl]-, ethyl ester

There total 5 articles about 4-Piperidinecarboxylic acid, 1-[(2E)-3-[3-chloro-4-[(2-methoxyphenyl)thio]-2-(trifluoromethyl)phenyl]-1 -oxo-2-propenyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-carbethoxypiperidine (1126-09-6) + (E)-3-[3-Chloro-4-(2-methoxy-phenylsulfanyl)-2-trifluoromethyl-phenyl]-acryloyl chloride → (2-methoxyphenyl)[2-chloro-3-trifluoromethyl-4-(E-((4-carboethoxypiperidin-1-yl)carbonyl)ethenyl)phenyl]sulfide (280752-12-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.333333h;

Reference yield:

3-chloro-4-hydroxy-2-(trifluoromethyl)benzaldehyde (280753-11-9) → (2-methoxyphenyl)[2-chloro-3-trifluoromethyl-4-(E-((4-carboethoxypiperidin-1-yl)carbonyl)ethenyl)phenyl]sulfide (280752-12-7)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 1 h / 25 °C

2: i-Pr₂NEt / acetonitrile / 0.3 h / 25 - 50 °C

3: piperidine / 1.5 h / 120 °C

4: oxalyl chloride / benzene / 0.75 h / Heating

5: toluene / 0.75 h / 25 °C

With piperidine; pyridine; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In toluene; acetonitrile; benzene;

DOI:10.1021/jm0103108

Reference yield:

4-(2-methoxyphenylthio)-2-chloro-3-(trifluoromethyl)benzaldehyde (381229-82-9) → (2-methoxyphenyl)[2-chloro-3-trifluoromethyl-4-(E-((4-carboethoxypiperidin-1-yl)carbonyl)ethenyl)phenyl]sulfide (280752-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / 1.5 h / 120 °C

2: oxalyl chloride / benzene / 0.75 h / Heating

3: toluene / 0.75 h / 25 °C

With piperidine; oxalyl dichloride; In toluene; benzene;

DOI:10.1021/jm0103108

upstream raw materials:

4-carbethoxypiperidine

3-chloro-4-hydroxy-2-(trifluoromethyl)benzaldehyde

4-(2-methoxyphenylthio)-2-chloro-3-(trifluoromethyl)benzaldehyde

4-trifloxy-3-chloro-2-(trifluoromethyl)benzaldehyde