4-(2-methoxyphenylthio)-2-chloro-3-(trifluoromethyl)benzaldehyde

Base Information

• Chemical Name: 4-(2-methoxyphenylthio)-2-chloro-3-(trifluoromethyl)benzaldehyde
• CAS No.: 381229-82-9
• Molecular Formula: C₁₅H₁₀ClF₃O₂S
• Molecular Weight: 346.757
• Mol file: 381229-82-9.mol

Synonyms:4-(2-methoxyphenylthio)-2-chloro-3-(trifluoromethyl)benzaldehyde

Chemical Property of 4-(2-methoxyphenylthio)-2-chloro-3-(trifluoromethyl)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-methoxyphenylthio)-2-chloro-3-(trifluoromethyl)benzaldehyde

There total 2 articles about 4-(2-methoxyphenylthio)-2-chloro-3-(trifluoromethyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methoxybenzenethiol (7217-59-6) + 4-trifloxy-3-chloro-2-(trifluoromethyl)benzaldehyde (381229-83-0) → 4-(2-methoxyphenylthio)-2-chloro-3-(trifluoromethyl)benzaldehyde (381229-82-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 25 - 50 ℃; for 0.3h;

DOI:10.1021/jm0103108

Reference yield:

2-chloro-3-(trifluoromethyl)phenol (138377-34-1) → 4-(2-methoxyphenylthio)-2-chloro-3-(trifluoromethyl)benzaldehyde (381229-82-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 10 percent / Ca(OH)2; aq. Na₂CO₃ / H₂O / 65 °C

2: pyridine / 1 h / 25 °C

3: i-Pr₂NEt / acetonitrile / 0.3 h / 25 - 50 °C

With pyridine; calcium hydroxide; sodium carbonate; N-ethyl-N,N-diisopropylamine; In water; acetonitrile; 1: Reimer-Tiemann reaction;

DOI:10.1021/jm0103108

Reference yield:

4-(2-methoxyphenylthio)-2-chloro-3-(trifluoromethyl)benzaldehyde (381229-82-9) → (2-methoxyphenyl)[2-chloro-3-trifluoromethyl-4-(E-((morpholin-1-yl)carbonyl)ethenyl)phenyl]sulfide

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / 1.5 h / 120 °C

2: oxalyl chloride / benzene / 0.75 h / Heating

3: toluene / 0.75 h / 25 °C

With piperidine; oxalyl dichloride; In toluene; benzene;

DOI:10.1021/jm0103108

upstream raw materials:

2-Methoxybenzenethiol

4-trifloxy-3-chloro-2-(trifluoromethyl)benzaldehyde

2-chloro-3-(trifluoromethyl)phenol

Downstream raw materials:

(2-methoxyphenyl)[2-chloro-3-trifluoromethyl-4-(E-carboxyethenyl)phenyl]sulfide

(2-methoxyphenyl)[2-chloro-3-trifluoromethyl-4-(E-((4-carboethoxypiperidin-1-yl)carbonyl)ethenyl)phenyl]sulfide