2,6-dioxo-N-(carboxymethyl)morpholine

Base Information

• Chemical Name: 2,6-dioxo-N-(carboxymethyl)morpholine
• CAS No.: 33658-49-0
• Molecular Formula: C6H7NO5
• Molecular Weight: 173.125
• Hs Code.: 2934999090
• Mol file: 33658-49-0.mol

Synonyms:(2,6-Dioxomorpholin-4-yl)acetic acid;

Chemical Property of 2,6-dioxo-N-(carboxymethyl)morpholine

Chemical Property:

• Vapor Pressure: 1.61E-08mmHg at 25°C
• Refractive Index: 1.523
• Boiling Point: 427.9 °C at 760 mmHg
• Flash Point: 212.6 °C
• PSA: 83.91000
• Density: 1.521 g/cm³
• LogP: -1.60570

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dioxo-N-(carboxymethyl)morpholine

There total 2 articles about 2,6-dioxo-N-(carboxymethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nitrilotriacetic acid (139-13-9,80751-51-5) → morpholine-1-(acetic acid)-2,6-dione (33658-49-0)

Guidance literature:

With pyridine; acetic anhydride; In N-methyl-acetamide;

Reference yield:

nitrilotriacetic acid (139-13-9,80751-51-5) + acetic anhydride (108-24-7) → morpholine-1-(acetic acid)-2,6-dione (33658-49-0)

Guidance literature:

With pyridine; at 40 ℃; for 5h;

Reference yield: 83.0%

morpholine-1-(acetic acid)-2,6-dione (33658-49-0) + benzyl 6-aminohexanoate (5515-01-5) → 2,2’-[(2-{[6-(benzyloxy)-6-oxohexyl]amino}-2-oxoethyl)azanediyl]diacetic acid (1357195-04-0)

Guidance literature:

In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

upstream raw materials:

nitrilotriacetic acid

acetic anhydride

Downstream raw materials:

2,2’-[(2-{[6-(benzyloxy)-6-oxohexyl]amino}-2-oxoethyl)azanediyl]diacetic acid

Refernces

• 1、 -. "METHOD FOR SYNTHESIZING TETRAALKYLNITRILOACETIC ACID DIACETAMIDE COMPOUND". Paragraph 0063-0064. . Retrieved 2019/04/14.
• 2、 -. "In order to amino-acetic acid derivatives as ligand complex compound and vanadium knid preparation method and application". Paragraph 0033-0035; 0052-0053; 0071-0073; 0090-0092. . Retrieved 2017/08/25.