Heptanoic acid, 2-methyl-3-oxo-, ethyl ester

Base Information

Chemical Name:Heptanoic acid, 2-methyl-3-oxo-, ethyl ester
CAS No.:2866-79-7
Molecular Formula:C10H18O3
Molecular Weight:186.251
Hs Code.:
Mol file:2866-79-7.mol

Synonyms:

Suppliers and Price of Heptanoic acid, 2-methyl-3-oxo-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of Heptanoic acid, 2-methyl-3-oxo-, ethyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Heptanoic acid, 2-methyl-3-oxo-, ethyl ester

There total 2 articles about Heptanoic acid, 2-methyl-3-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 623-73-4
diazoacetic acid ethyl ester

: 591-78-6
n-hexan-2-one

: 2866-79-7
ethyl 2-methyl-3-oxoheptanoate

: 1540-29-0
ethyl 2-butylacetoacetate

Guidance literature:: n-hexan-2-one; With tetrafluoroboric acid diethyl ether; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere; Schlenk technique;

diazoacetic acid ethyl ester; In dichloromethane; at 20 ℃; for 72h; Overall yield = 55 percent; Overall yield = 0.51 g; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.joc.0c02972

Reference yield:

: 2-Diazo-3-hydroxy-3-methyl-heptanoic acid ethyl ester

: 2866-79-7
ethyl 2-methyl-3-oxoheptanoate

: 1540-29-0
ethyl 2-butylacetoacetate

Guidance literature:: palladium dichloride; In benzene; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;
DOI:10.1055/s-1983-30277

Reference yield:

: 2866-79-7
ethyl 2-methyl-3-oxoheptanoate

: C₁₉H₂₀O₄

Guidance literature:: Multi-step reaction with 7 steps

1.1: LDA / cyclohexane; tetrahydrofuran / 2 h / -78 °C

2.1: 9.71 g / DBU / benzene / 6 h / Heating

3.1: 89 percent / pyridine / 44 h / 20 °C

4.1: 99 percent / SeO₂ / dioxane / 21 h / 130 °C

5.1: 91 percent / NaBH₄ / ethanol / 4 h / 20 °C

6.1: 99 percent / PBr₃ / dioxane / 15.5 h

7.1: diethyl ether / 1 h / -78 °C

7.2: CuBr / diethyl ether / 16 h / -78 - 20 °C

With pyridine; sodium tetrahydroborate; selenium(IV) oxide; phosphorus tribromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; cyclohexane; benzene;
DOI:10.1021/jo070327j