2-AMINO-3-(2-FLUORO-4-HYDROXY-PHENYL)-PROPIONIC ACID

Base Information

• Chemical Name: 2-AMINO-3-(2-FLUORO-4-HYDROXY-PHENYL)-PROPIONIC ACID
• CAS No.: 7656-31-7
• Molecular Formula: C9H10FNO3
• Molecular Weight: 199.182
• Hs Code.: 2922498590
• Mol file: 7656-31-7.mol

Synonyms:2-Fluor-tyrosin;2-fluoro-tyrosine;Tyrosine,L;2-Fluoro-DL-tyrosine;

Chemical Property of 2-AMINO-3-(2-FLUORO-4-HYDROXY-PHENYL)-PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 9.64E-07mmHg at 25°C
• Boiling Point: 388.8°Cat760mmHg
• Flash Point: 189°C
• PSA: 83.55000
• Density: 1.421g/cm³
• LogP: 1.18600

Purity/Quality:

97% ^*data from raw suppliers

2'-Fluoro-DL-tyrosine 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-3-(2-FLUORO-4-HYDROXY-PHENYL)-PROPIONIC ACID

There total 6 articles about 2-AMINO-3-(2-FLUORO-4-HYDROXY-PHENYL)-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-O-methyl-tyrosine (54788-29-3) → o-fluoro-DL-tyrosine (7656-31-7)

Guidance literature:

2-fluoro-O-methyl-tyrosine; With water; hydrogen bromide; at 100 ℃; for 6h;

With ammonia; water; pH=8;

Reference yield:

acetylamino-(2-fluoro-4-methoxy-benzyl)-malonic acid diethyl ester (428-81-9) → o-fluoro-DL-tyrosine (7656-31-7)

Guidance literature:

With hydrogen bromide;

DOI:10.1021/jm00235a006

Reference yield:

N-acetyl-2-fluoro-O-methyl-tyrosine (349-18-8) → o-fluoro-DL-tyrosine (7656-31-7)

Guidance literature:

With hydrogen bromide;

DOI:10.1021/ja01160a113

upstream raw materials:

N-acetyl-2-fluoro-O-methyl-tyrosine

acetylamino-(2-fluoro-4-methoxy-benzyl)-malonic acid diethyl ester

1-(chloromethyl)-2-fluoro-4-methoxybenzene

2-Fluor-4-methoxybenzoesaurechlorid

Downstream raw materials:

2-tert-butoxycarbonylamino-3-(2-fluoro-4-hydroxyphenyl)propionic acid

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