6-Methoxy-2-methylbenzofuran

Base Information

• Chemical Name: 6-Methoxy-2-methylbenzofuran
• CAS No.: 29040-48-0
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID50515174
• Nikkaji Number: J2.208.038E
• Wikidata: Q82375929
• Mol file: 29040-48-0.mol

Synonyms:6-Methoxy-2-methylbenzofuran;29040-48-0;6-methoxy-2-methyl-1-benzofuran;6-methoxy-2-methyl-benzofuran;6-methoxy-2methylbenzofuran;SCHEMBL719714;DTXSID50515174;AHAVOXPDABUPJT-UHFFFAOYSA-N;AKOS006311701

Chemical Property of 6-Methoxy-2-methylbenzofuran

Chemical Property:

• Boiling Point: 122 °C(Press: 12 Torr)
• PSA: 22.37000
• Density: 1.106±0.06 g/cm3(Predicted)
• LogP: 2.74980
• Storage Temp.: 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 162.068079557
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

99% ^*data from raw suppliers

6-Methoxy-2-methylbenzofuran 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(O1)C=C(C=C2)OC

Technology Process of 6-Methoxy-2-methylbenzofuran

There total 8 articles about 6-Methoxy-2-methylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-iodo-5-methoxyphenol (41046-70-2) + prop-1-yne (74-99-7) → 6-methoxy-2-methylbenzofuran (29040-48-0)

Guidance literature:

With copper(l) iodide; N,N,N',N'-tetramethylguanidine; bis-triphenylphosphine-palladium(II) chloride; In DMF (N,N-dimethyl-formamide); at -78 - 20 ℃; for 18h;

Reference yield: 71.0%

calcium carbide + C15H16N2O4S (678554-43-3) → 6-methoxy-2-methylbenzofuran (29040-48-0)

Guidance literature:

With potassium tert-butylate; water; copper(l) chloride; In N,N-dimethyl-formamide; at 90 ℃; for 5h;

DOI:10.1021/acs.orglett.8b00676

Reference yield:

3-allyloxyanisole (37592-19-1) → 4-methoxy-2-methylbenzofuran (3781-89-3) + 6-methoxy-2-methylbenzofuran (29040-48-0)

Guidance literature:

With sodium carbonate; p-benzoquinone; dichloro bis(acetonitrile) palladium(II); In 1,4-dioxane; at 80 ℃; Title compound not separated from byproducts;

DOI:10.1021/ol051264z

upstream raw materials:

4-methoxybenzyl methyl ketone

Acetone O-(m-methoxyphenyl)oxime

m-methoxyphenyl 2-propynyl ether

3-allyloxyanisole

Downstream raw materials:

6-methoxy-2-methylbenzofuran-3-carboxylic acid methylamide

6-hydroxy-2-methylbenzofuran