Benzoic acid, 3-(4-morpholinylmethyl)-, 3-[5-[[[(4-chlorophenyl)methyl]amino]carbonyl]-7-ethyl-4,7-dihydro-4-oxo thieno[2,3-b]pyridin-2-yl]-2-propynyl ester

Base Information

Chemical Name:Benzoic acid, 3-(4-morpholinylmethyl)-, 3-[5-[[[(4-chlorophenyl)methyl]amino]carbonyl]-7-ethyl-4,7-dihydro-4-oxo thieno[2,3-b]pyridin-2-yl]-2-propynyl ester
CAS No.:292144-06-0
Molecular Formula:C32H30ClN3O5S
Molecular Weight:604.126
Hs Code.:

Benzoic acid, 3-(4-morpholinylmethyl)-,
3-[5-[[[(4-chlorophenyl)methyl]amino]carbonyl]-7-ethyl-4,7-dihydro-4-oxo
thieno[2,3-b]pyridin-2-yl]-2-propynyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid, 3-(4-morpholinylmethyl)-, 3-[5-[[[(4-chlorophenyl)methyl]amino]carbonyl]-7-ethyl-4,7-dihydro-4-oxo thieno[2,3-b]pyridin-2-yl]-2-propynyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Benzoic acid, 3-(4-morpholinylmethyl)-, 3-[5-[[[(4-chlorophenyl)methyl]amino]carbonyl]-7-ethyl-4,7-dihydro-4-oxo thieno[2,3-b]pyridin-2-yl]-2-propynyl ester

There total 4 articles about Benzoic acid, 3-(4-morpholinylmethyl)-, 3-[5-[[[(4-chlorophenyl)methyl]amino]carbonyl]-7-ethyl-4,7-dihydro-4-oxo thieno[2,3-b]pyridin-2-yl]-2-propynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 292143-74-9
N-(4-chlorobenzyl)-7-ethyl-2-(3-hydroxy-1-propynyl)-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide

: 110-91-8,99108-56-2
morpholine

: 63024-77-1
3-(Chloromethyl)benzoyl chloride

: 292144-06-0
3-(5-{[(4-Chlorobenzyl)amino]carbonyl}-7-ethyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridin-2-yl)-2-propynyl 3-(4-morpholinylmethyl)benzoate

Guidance literature:: With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: N-(4-chlorobenzyl)-7-ethyl-2-iodo-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide

: 292144-06-0
3-(5-{[(4-Chlorobenzyl)amino]carbonyl}-7-ethyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridin-2-yl)-2-propynyl 3-(4-morpholinylmethyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(PPh₃)2Cl₂ / diethylamine

2: potassium carbonate; triethylamine / dichloromethane; N,N-dimethyl-formamide

With potassium carbonate; triethylamine; Pd(PPh₃)2Cl₂; In dichloromethane; diethylamine; N,N-dimethyl-formamide;

Reference yield:

: 104-86-9
4-chlorobenzylamine

: 292144-06-0
3-(5-{[(4-Chlorobenzyl)amino]carbonyl}-7-ethyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridin-2-yl)-2-propynyl 3-(4-morpholinylmethyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide

2: Pd(PPh₃)2Cl₂ / diethylamine

3: potassium carbonate; triethylamine / dichloromethane; N,N-dimethyl-formamide

With potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; Pd(PPh₃)2Cl₂; In dichloromethane; diethylamine; N,N-dimethyl-formamide;