(r)-(+)-Propafenone hydrochloride

Base Information

• Chemical Name: (r)-(+)-Propafenone hydrochloride
• CAS No.: 107381-35-1
• Molecular Formula: C₂₁H₂₇NO₃*ClH
• Molecular Weight: 377.911
• DSSTox Substance ID: DTXSID70910304
• Mol file: 107381-35-1.mol

Synonyms:107381-35-1;(r)-(+)-propafenone hydrochloride;(R)-Propafenone hydrochloride;Lu 44215;1-[2-[(2R)-2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride;DTXSID70910304;EN300-19785969;1-{2-[(2R)-2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one hydrochloride;1-{2-[2-Hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one--hydrogen chloride (1/1)

Chemical Property of (r)-(+)-Propafenone hydrochloride

Chemical Property:

• Vapor Pressure: 1.27E-11mmHg at 25°C
• Boiling Point: 519.6°Cat760mmHg
• Flash Point: 268°C
• PSA: 58.56000
• Density: g/cm³
• LogP: 4.43430
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 11
• Exact Mass: 377.1757714
• Heavy Atom Count: 26
• Complexity: 368

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

(R)-(+)-PROPAFENONE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 46-22
• Safety Statements: 53-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl
• Isomeric SMILES: CCCNC[C@H](COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl

Technology Process of (r)-(+)-Propafenone hydrochloride

There total 9 articles about (r)-(+)-Propafenone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R-(2α(R*),3aα,4α,7α,7aα))-1-(2-(2-(2-Octahydro-7,8,8-trimethyl-4,7-methano-2-benzofuranyloxy)-3-propylamino-propoxy)-phenyl)-3-phenyl-1-propanon → (+)-Propafenone hydrochloride (107381-35-1)

Guidance literature:

With hydrogenchloride; methanol; In diethyl ether;

DOI:10.1002/ardp.19943271104

Reference yield:

2'-hydroxy-3-phenylpropiophenone (3516-95-8) → (+)-Propafenone hydrochloride (107381-35-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 62.8 percent / TsOH / benzene / 86 h / Heating

2: 90 percent / NaH / dimethylformamide / 3 h / 50 °C

3: 81 percent / 2 h / Heating

4: 2 N HCl / 1 h / 80 °C

With hydrogenchloride; sodium hydride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; benzene;

DOI:10.1007/BF00807638

Reference yield:

2-(2-phenethyl-1,3-dioxolan-2-yl)phenol (189766-45-8) → (+)-Propafenone hydrochloride (107381-35-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / NaH / dimethylformamide / 3 h / 50 °C

2: 81 percent / 2 h / Heating

3: 2 N HCl / 1 h / 80 °C

With hydrogenchloride; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1007/BF00807638

upstream raw materials:

propylamine

Toluene-4-sulfonic acid (S)-2-hydroxy-3-[2-(3-phenyl-propionyl)-phenoxy]-propyl ester

(S)-1-{2-[2-(2-phenylethyl)-1,3-dioxolan-2-yl]phenoxy}-3-propylamino-2-propanol

2'-hydroxy-3-phenylpropiophenone