Propylamine

Base Information

• Chemical Name: Propylamine
• CAS No.: 107-10-8
• Deprecated CAS: 42939-71-9
• Molecular Formula: C3H9N
• Molecular Weight: 59.1112
• Hs Code.: 2921.19 Oral, rat LD50: 570 mg/kg
• European Community (EC) Number: 203-462-3
• ICSC Number: 0941
• NSC Number: 7490
• UN Number: 1277
• UNII: I76F18D635
• DSSTox Substance ID: DTXSID6021878
• Nikkaji Number: J4.052E
• Wikipedia: Propylamine
• Wikidata: Q417852
• Metabolomics Workbench ID: 46327
• ChEMBL ID: CHEMBL14409
• Mol file: 107-10-8.mol

Synonyms:Propylamine;Propan-1-amine;107-10-8;1-Propanamine;1-Propylamine;n-Propylamine;Propanamine;1-AMINOPROPANE;Mono-n-propylamine;Monopropylamine;RCRA waste number U194;propyl amine;n-Propyl Amine;Propan-1-ylamine;NSC 7490;(n-Propan-1-yl)amine;HSDB 5162;n-C3H7NH2;EINECS 203-462-3;UNII-I76F18D635;CHEBI:39870;AI3-26456;NSC-7490;UN1277;RCRA waste no. U194;I76F18D635;DTXSID6021878;FEMA NO. 4237;EC 203-462-3;MFCD00008205;N-PROPYL-3,3,3-D3-AMINE;Propylamine [UN1277] [Flammable liquid];58479-39-3;68130-69-8;68130-70-1;68187-43-9;68187-44-0;68187-45-1;AYE;3-AMINOPROPYL;aminopropane;Monopropilamina;Propilamina;n-propilamina;propylamin-;1-aminopropano;n-propyl-amine;1-propanamina;1-propilamina;3-propylamine;N-n-propylamine;propane-1-amine;2-methylethylamine;mono-n-propilamina;Propan-1-ilamina;n-prop-1-ylamine;Propanamine, 9CI;Propylamine (8CI);Propylamine, 98%;Propylamine (normal);PrNH2;PRA (CHRIS Code);Propylamine, >=99%;PROPYLAMINE [MI];3-Aminopropyl Silica Gel;PROPYLAMINE [FHFI];NH2CH2CH2CH3;WLN: Z3;CHEMBL14409;1-AMINOPROPANE [HSDB];DTXCID001878;Propylamine, analytical standard;NSC7490;Propanamine, 1-;(Propylamine);BCP18818;STR01427;EINECS 268-601-2;EINECS 268-602-8;EINECS 269-096-1;EINECS 269-097-7;EINECS 269-098-2;NA1277;STL185558;AKOS000120278;UN 1277;Propylamine, purum, >=99.0% (GC);LS-125523;FT-0656405;P0520;PROPYLAMINE (NORMAL) (N-PROPYLAMINE);Propylamine [UN1277] [Flammable liquid];EN300-20505;A801584;Q417852;J-001703;F2190-0357

Chemical Property of Propylamine

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 329mmHg at 25°C
• Melting Point: -83 °C
• Refractive Index: 1.392
• Boiling Point: 46.943 °C at 760 mmHg
• PKA: 10.66±0.10(Predicted)
• Flash Point: -30 °C
• PSA: 26.02000
• Density: 0.723 g/cm³
• LogP: 1.05540
• Water Solubility.: soluble
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 59.073499291
• Heavy Atom Count: 4
• Complexity: 7.2
• Transport DOT Label: Flammable Liquid Corrosive

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F:Flammable;;
• Statements: R11:; R20/21/22:; R34:
• Safety Statements: S16:; S26:; S36/37/39:; S45:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CCCN
• Inhalation Risk: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. Exposure could cause severe swelling of the throat.
• Effects of Long Term Exposure: Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the respiratory tract and lungs. This may result in chronic inflammation and impaired functions.

Technology Process of Propylamine

There total 209 articles about Propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1,3-dipropylurea (623-95-0) + sodium p-toluenesulfonamide (18522-92-4) → propylamine (107-10-8,42939-71-9) + 4-methyl-N-( propylcarbamoyl)benzenesulfonamide (24570-88-5)

Guidance literature:

at 150 ℃; for 6h; Product distribution; other time;;

Reference yield: 38.0%

formic acid (64-18-6) + 1-amino-2-propene (107-11-9,30551-89-4) → propylamine (107-10-8,42939-71-9) + DL-3-aminoisobutyric acid (10569-72-9) + glycine (56-40-6,18875-39-3,25718-94-9) + 3-amino propanoic acid (107-95-9) + 4-amino-n-butyric acid (56-12-2)

Guidance literature:

With hydrogen; oxygen; In water; for 3h; Product distribution; various unsaturated amines; investigation of the direct carboxylation of C=C bond, the effect of formic acid concentration as well as the flame composition on product(s); radical mechanism is proposed;

DOI:10.1246/cl.1985.145

Reference yield:

ethanol (64-17-5) + trimethyl(n-propylamino)silane (18182-24-6) → propylamine (107-10-8,42939-71-9) + ethyl trimethylsilyl ether (1825-62-3)

Guidance literature:

In benzene; at 30 ℃; for 5h; Rate constant; Equilibrium constant; Mechanism;

upstream raw materials:

propan-1-ol

2-iodo-propane

O-Methylhydroxylamin

n-propylmagnesium bromide

Downstream raw materials:

bis[2-(N-n-propylcarbamoyl)phenyl] disulfide

N-propyltetrahydrofurfurylamine

propyl-(2-[2]pyridyl-ethyl)-amine

1-(3-propyl)-pyrrolidin-2-one

Refernces

• 1、 Boyd et al.. "". . p. 2283,2284, 2287, 2288. Retrieved 1971.
• 2、 Morimoto, Toshiaki,Takahashi, Toshio,Sekiya, Minoru. "N,N-Bis(trimethylsilyl)methoxymethylamine as a Convenient Synthetic Equivalent for +CH2NH2: Primary Aminomethylation of Organometallic Compounds". . p. 794 - 795. Retrieved 1984.
• 3、 Coleman,Hermanson,Johnson. "-". . p. 1896. Retrieved 1937.
• 4、 Alvarez, Julio,Liu, Jian,Roman, Esteban,Kaifer, Angel E.. "Water-soluble platinum and palladium nanoparticles modified with thiolated β-cyclodextrin". . p. 1151 - 1152. Retrieved 2000.
• 5、 Mohammed, Fiaz S.,Kitchens, Christopher L.. "Reduced reactivity of amines against nucleophilic substitution via reversible reaction with carbon dioxide". . . Retrieved 2016.
• 6、 Grechin, Alexander G.,Buschmann, Hans-Juergen,Schollmeyer, Eckhard. "Supramolecular solid-gas complexes: A thermodynamic approach". . p. 6499 - 6501. Retrieved 2007.
• 7、 Rooley et al.. "-". . p. 1082. Retrieved 1952.
• 8、 Mukaiyama,Fujita. "-". . p. 54. Retrieved 1956.
• 9、 Coeck, Robin,Berden, Sarah,De Vos, Dirk E.. "Sustainable hydrogenation of aliphatic acyclic primary amides to primary amines with recyclable heterogeneous ruthenium-tungsten catalysts". . p. 5326 - 5335. Retrieved 2019.
• 10、 Reinert, Susanne,Mohr, Gerhard J.. "Chemosensor for the optical detection of aliphatic amines and diamines". . p. 2272 - 2274. Retrieved 2008.