4-(2-Fluoroethoxy)benzaldehyde

Base Information

• Chemical Name: 4-(2-Fluoroethoxy)benzaldehyde
• CAS No.: 2967-92-2
• Molecular Formula: C9H9FO2
• Molecular Weight: 168.168
• Hs Code.: 2913000090
• DSSTox Substance ID: DTXSID00567668
• Wikidata: Q82453637
• Mol file: 2967-92-2.mol

Synonyms:4-(2-Fluoroethoxy)benzaldehyde;2967-92-2;4-(2-fluoro-ethoxy)-benzaldehyde;4-(2-FLUOROETHOXY)-BENZALDEHYDE;SCHEMBL1982944;DTXSID00567668;INJGNPMZUJFVFK-UHFFFAOYSA-N;CAA96792;AKOS006325605;CS-0316243;A1-02732

Chemical Property of 4-(2-Fluoroethoxy)benzaldehyde

Chemical Property:

• PSA: 26.30000
• LogP: 1.84740
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 168.05865769
• Heavy Atom Count: 12
• Complexity: 131

Purity/Quality:

95% ^*data from raw suppliers

4-(2-Fluoro-ethoxy)-benzaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C=O)OCCF

Technology Process of 4-(2-Fluoroethoxy)benzaldehyde

There total 8 articles about 4-(2-Fluoroethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-fluoroethyl tosylate (383-50-6) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(2-fluoro-ethoxy)-benzaldehyde (2967-92-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.07.026

Reference yield: 99.0%

2-fluoroethyl bromide (762-49-2) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(2-fluoro-ethoxy)-benzaldehyde (2967-92-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 5h;

DOI:10.1002/jlcr.3408

Reference yield: 87.8%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(2-fluoro-ethoxy)-benzaldehyde (2967-92-2)

Guidance literature:

4-hydroxy-benzaldehyde; With potassium hydroxide; In ethanol; at 80 ℃; for 0.5h;

1-halo-2-fluoroethane; In ethanol; at 80 ℃; for 1h;

DOI:10.1039/c6ra05168e

upstream raw materials:

2-fluoroethyl tosylate

4-hydroxy-benzaldehyde

4-(2-hydroxy-ethoxy)-benzaldehyde

2-fluoroethanol

Downstream raw materials:

C₁₉H₂₂ClFN₂O

C₂₀H₂₅FN₂O₂

1-(2-fluoroethoxy)-4-(bromomethyl)benzene

4-(2-fluoroethoxy)benzoyl chloride

Refernces

• 1、 Devi, Kavita,Rajendran, Vinoth,Ayushee,Rangarajan,Singh, Rishi Pal,Ghosh, Prahlad C.,Singh, Manjula. "Synthesis and evaluation of antiplasmodial activity of 2,2,2-trifluoroethoxychalcones and 2-fluoroethoxy chalcones against plasmodium falciparum in culture". . . Retrieved 2018/05/26.
• 2、 Cui, Xiaomei,Zhang, Xiaoyang,Peng, Cheng,Dai, Jiapei,Liu, Boli,Cui, Mengchao. "Radiolabeled pyridinyl analogues of dibenzylideneacetone as β-amyloid imaging probes". . p. 44646 - 44654. Retrieved 2016/06/09.