1-Bromo-2-fluoroethane

Base Information

• Chemical Name: 1-Bromo-2-fluoroethane
• CAS No.: 762-49-2
• Molecular Formula: C2H4BrF
• Molecular Weight: 126.956
• European Community (EC) Number: 212-100-3
• NSC Number: 172603
• UNII: 9B15FC1III
• DSSTox Substance ID: DTXSID6073233
• Nikkaji Number: J130.690A
• Wikidata: Q27272288
• Mol file: 762-49-2.mol

Synonyms:1-bromo-2-fluoroethane;2-fluoroethyl bromide;2-fluoroethyl bromide, 18F-labeled

Chemical Property of 1-Bromo-2-fluoroethane

Chemical Property:

• Appearance/Colour: clear colourless liquid
• Vapor Pressure: 147mmHg at 25°C
• Melting Point: 70-72 °C
• Refractive Index: n20/D 1.424(lit.)
• Boiling Point: 69.3 °C at 760 mmHg
• Flash Point: -1 °C
• PSA: 0.00000
• Density: 1.583 g/cm³
• LogP: 1.35080
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 125.94804
• Heavy Atom Count: 4
• Complexity: 10

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-2-fluoroethane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, N, T+, F
• Hazard Codes: Xi,N,T+,F
• Statements: 11-28-36/37/38-59
• Safety Statements: 16-26-33-36/37/39-59-45-36/37-28

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Solvents -> Brominated Solvents
• Canonical SMILES: C(CBr)F

Technology Process of 1-Bromo-2-fluoroethane

There total 17 articles about 1-Bromo-2-fluoroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-bromoethanol (540-51-2) → 2-fluoroethyl bromide (762-49-2)

Guidance literature:

With dimethylaminosulphur trifluoride; In diethylene glycol dimethyl ether; at -50 - 20 ℃;

Reference yield: 32.0%

→ 2-fluoroethyl bromide (762-49-2)

Guidance literature:

Reference yield:

ethylene glycol (107-21-1) + ethylene dibromide (106-93-4) → Vinyl bromide (593-60-2,25951-54-6) + 2-fluoroethyl bromide (762-49-2)

Guidance literature:

at 150 ℃;

upstream raw materials:

2-fluoroethanol

2-bromoethyl methanesulfonate

2-bromoethyl p-toluenesulfonate

ethylene dibromide

Downstream raw materials:

2-fluoro-N-methyl-N-(naphthalen-1-ylmethyl)ethanamine

ethyl-(2-fluoro-ethyl)-[1]naphthylmethyl-amine

(2-fluoro-ethyl)-phosphonic acid diethyl ester

tetraethyl ethylenebis(phosphonate)

Refernces

¹⁸F-Labelled vorozole analogues as PET tracer for aromatase

10.1002/jlcr.1502

The research aims to develop 18F-labeled vorozole analogues as PET tracers for detecting the enzyme aromatase, which converts androgens to estrogens and may influence mood and mental status. The study involves one- and two-step syntheses of two 18F-labeled vorozole analogues, [18F]FVOZ and [18F]FVOO, using key chemicals such as ethane-1,2-diyl bis(4-methylbenzenesulfonate), oxydiethane-2,1-diyl bis(4-methylbenzenesulfonate), and 1-bromo-2-fluoroethane. The one-step synthesis achieved higher radiochemical yields (36–99%) and specific radioactivities (100 GBq/mmol for [18F]FVOZ and 80 GBq/mmol for [18F]FVOO) compared to the two-step synthesis. In vitro autoradiography using frozen rat brains showed specific binding in regions corresponding to previous [11C]VOZ studies. Metabolite studies revealed that [18F]FVOZ was more stable in plasma than [18F]FVOO. The one-step synthesis method is highlighted as a more reproducible and potentially automatable approach for future tracer development.