ethyl 3-amino-4-(4-chlorophenyl)-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylate

Base Information

Chemical Name:ethyl 3-amino-4-(4-chlorophenyl)-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylate
CAS No.:296797-45-0
Molecular Formula:C20H15ClN2O2S2
Molecular Weight:414.92800
Hs Code.:
Mol file:296797-45-0.mol

Synonyms:3-Amino-4-(4-chloro-phenyl)-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid ethyl ester;

Suppliers and Price of ethyl 3-amino-4-(4-chlorophenyl)-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 3-amino-4-(4-chlorophenyl)-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylate

Chemical Property:

Melting Point:178 - 180 °C (methanol)
PSA：121.69000
LogP:6.68530

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of ethyl 3-amino-4-(4-chlorophenyl)-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylate

There total 4 articles about ethyl 3-amino-4-(4-chlorophenyl)-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 300844-09-1
[4-(4-chloro-phenyl)-3-cyano-6-thiophen-2-yl-pyridin-2-ylsulfanyl]-acetic acid ethyl ester

: 296797-45-0
3-amino-4-(4-chlorophenyl)-6-thien-2-ylthieno[2,3-b]pyridine-2-carboxylic acid ethyl ester

Guidance literature:: With sodium ethanolate; In ethanol; for 0.0833333h; Heating;
DOI:10.1080/10426500490467147

Reference yield: 70.0%

: 105-39-5
chloroacetic acid ethyl ester

: 82127-15-9
4-(4-chlorophenyl)-6-(thien-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile

: 296797-45-0
3-amino-4-(4-chlorophenyl)-6-thien-2-ylthieno[2,3-b]pyridine-2-carboxylic acid ethyl ester

Guidance literature:: With sodium ethanolate; In ethanol; Reflux;

Reference yield:

: 79442-37-8,6028-96-2
3-(4-chlorophenyl)-1-(thiophen-2-yl)prop-2-en-1-one

: 296797-45-0
3-amino-4-(4-chlorophenyl)-6-thien-2-ylthieno[2,3-b]pyridine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / piperidine / ethanol / 4 h / Heating

2: 95 percent / sodium acetate trihydrate / ethanol / 2 h / Heating

3: 89 percent / NaOEt / ethanol / 0.08 h / Heating

With piperidine; sodium ethanolate; sodium acetate; In ethanol;
DOI:10.1080/10426500490467147