2-pyrrolidin-1-yl-N-[4-[[4-[(2-pyrrolidin-1-ylacetyl)amino]phenyl]methyl]phenyl]acetamide

Base Information

Chemical Name:2-pyrrolidin-1-yl-N-[4-[[4-[(2-pyrrolidin-1-ylacetyl)amino]phenyl]methyl]phenyl]acetamide
CAS No.:298215-35-7
Molecular Formula:C25H32N4O2
Molecular Weight:420.555
Hs Code.:
DSSTox Substance ID:DTXSID30404012
Nikkaji Number:J2.491.675H
Wikidata:Q82207953
ChEMBL ID:CHEMBL477328
Mol file:298215-35-7.mol

Synonyms:298215-35-7;GNF-PF-3071;2-pyrrolidin-1-yl-N-[4-[[4-[(2-pyrrolidin-1-ylacetyl)amino]phenyl]methyl]phenyl]acetamide;CHEMBL477328;2-(pyrrolidin-1-yl)-N-[4-({4-[2-(pyrrolidin-1-yl)acetamido]phenyl}methyl)phenyl]acetamide;SCHEMBL6279470;DTXSID30404012;BDBM50496217;AKOS005106967;JS-0429;2-(1-pyrrolidinyl)-N-[4-(4-{[2-(1-pyrrolidinyl)acetyl]amino}benzyl)phenyl]acetamide;SR-01000307704;SR-01000307704-1;1-pyrrolidineacetamide, N,N'-(methylene-di-4,1-phenylene)bis-1-pyrrolidineacetamide;2-Pyrrolidin-1-yl-N-[4-[4-(2-pyrrolidin-1-yl-acetylamino)-benzyl]-phenyl]-acetamide

Suppliers and Price of 2-pyrrolidin-1-yl-N-[4-[[4-[(2-pyrrolidin-1-ylacetyl)amino]phenyl]methyl]phenyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-(1-PYRROLIDINYL)-N-(4-(4-((2-(1-PYRROLIDINYL)ACETYL)AMINO)BENZYL)PHENYL)ACETAMIDE 95.00%
5MG
$ 687.35

American Custom Chemicals Corporation
2-(1-PYRROLIDINYL)-N-(4-(4-((2-(1-PYRROLIDINYL)ACETYL)AMINO)BENZYL)PHENYL)ACETAMIDE 95.00%
10MG
$ 679.14

Total 1 raw suppliers

Chemical Property of 2-pyrrolidin-1-yl-N-[4-[[4-[(2-pyrrolidin-1-ylacetyl)amino]phenyl]methyl]phenyl]acetamide

Chemical Property:

PSA：64.68000
LogP:3.36780
XLogP3:4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:420.25252628
Heavy Atom Count:31
Complexity:520

Purity/Quality:: 2-(1-PYRROLIDINYL)-N-(4-(4-((2-(1-PYRROLIDINYL)ACETYL)AMINO)BENZYL)PHENYL)ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(C1)CC(=O)NC2=CC=C(C=C2)CC3=CC=C(C=C3)NC(=O)CN4CCCC4

Technology Process of 2-pyrrolidin-1-yl-N-[4-[[4-[(2-pyrrolidin-1-ylacetyl)amino]phenyl]methyl]phenyl]acetamide

There total 2 articles about 2-pyrrolidin-1-yl-N-[4-[[4-[(2-pyrrolidin-1-ylacetyl)amino]phenyl]methyl]phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 123-75-1
pyrrolidine

: 10328-56-0
N,N'-(methylenedi-4,1-phenylene)bis(2-bromoacetamide)

: 298215-35-7
N,N'-(methylenedi-4,1-phenylene)bis[2-(1-pyrrolidinyl)acetamide]

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 60 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.12.132

Reference yield:

: 101-77-9
4,4'-diamino diphenyl methane

: 298215-35-7
N,N'-(methylenedi-4,1-phenylene)bis[2-(1-pyrrolidinyl)acetamide]

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; dmap / dichloromethane / 0 - 25 °C / Inert atmosphere

2: potassium carbonate / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

With pyridine; dmap; potassium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2010.12.132

Reference yield: 91.0%

: 298215-35-7
N,N'-(methylenedi-4,1-phenylene)bis[2-(1-pyrrolidinyl)acetamide]

: N,N'-bis[2-(1-pyrrolidinyl)ethyl]-4,4'-diaminodiphenylmethane

Guidance literature:: N,N'-(methylenedi-4,1-phenylene)bis[2-(1-pyrrolidinyl)acetamide]; With lithium aluminium tetrahydride; In tetrahydrofuran; for 24h; Inert atmosphere; Reflux;

With Glauber's salt; In tetrahydrofuran; for 1h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmcl.2010.12.132