2-Morpholinone, 4,5-dimethyl-3,6-diphenyl-, (3R,5S,6R)-

Base Information

Chemical Name:2-Morpholinone, 4,5-dimethyl-3,6-diphenyl-, (3R,5S,6R)-
CAS No.:29843-11-6
Molecular Formula:C18H19NO2
Molecular Weight:281.354
Hs Code.:
DSSTox Substance ID:DTXSID80434627
Nikkaji Number:J618.997K,J781.973K
Wikidata:Q82249090

Synonyms:2-Morpholinone, 4,5-dimethyl-3,6-diphenyl-, (3R,5S,6R)-;29843-11-6;DTXSID80434627;(3R,5S,6R)-4,5-dimethyl-3,6-diphenylmorpholin-2-one;3beta,6beta-Diphenyl-4alpha,5beta-dimethylmorpholin-2-one

Suppliers and Price of 2-Morpholinone, 4,5-dimethyl-3,6-diphenyl-, (3R,5S,6R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Morpholinone, 4,5-dimethyl-3,6-diphenyl-, (3R,5S,6R)-

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:281.141578849
Heavy Atom Count:21
Complexity:358

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(OC(=O)C(N1C)C2=CC=CC=C2)C3=CC=CC=C3
Isomeric SMILES:C[C@H]1[C@H](OC(=O)[C@H](N1C)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 2-Morpholinone, 4,5-dimethyl-3,6-diphenyl-, (3R,5S,6R)-

There total 5 articles about 2-Morpholinone, 4,5-dimethyl-3,6-diphenyl-, (3R,5S,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 710307-06-5
2--2-phenylethanenitrile

: 29843-11-6
(3R,5S,6R)-4,5-dimethyl-3,6-diphenylperhydro-1,4-oxazin-2-one

Guidance literature:: With hydrogenchloride; In benzene; at 27 ℃; for 48h;

Reference yield:

: 29843-10-5,97906-86-0
(R)-[((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amino]-phenyl-acetonitrile

: 29843-11-6
(3R,5S,6R)-4,5-dimethyl-3,6-diphenylperhydro-1,4-oxazin-2-one

Guidance literature:: With hydrogenchloride; In benzene; for 2h; Ambient temperature;
DOI:10.1021/jo00815a011

Reference yield:

: 299-42-3,7009-81-6,90-83-5,6912-63-6
ephedrine

: 1075-06-5
2,2-dihydroxy-1-phenyl-ethanone

: (3S,5S,6R)-4,5-dimethyl-3,6-diphenyl-morpholin-2-one

: 29843-11-6
(3R,5S,6R)-4,5-dimethyl-3,6-diphenylperhydro-1,4-oxazin-2-one

Guidance literature:: With magnesium sulfate; trifluoroacetic acid; In toluene; at 75 ℃; for 12h; Overall yield = 88 %; Overall yield = 248 mg; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/acs.joc.8b01516