Technology Process of 1-Piperidinecarboxylic acid,
2-[2-oxo-3-(4-oxo-3(4H)-quinazolinyl)propyl]-3-(phenylmethoxy)-,
phenylmethyl ester, (2R,3S)-
There total 41 articles about 1-Piperidinecarboxylic acid,
2-[2-oxo-3-(4-oxo-3(4H)-quinazolinyl)propyl]-3-(phenylmethoxy)-,
phenylmethyl ester, (2R,3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydride;
In
N,N-dimethyl-formamide;
at 0 - 70 ℃;
for 10.5h;
DOI:10.3987/COM-05-S(T)12
- Guidance literature:
-
Multi-step reaction with 23 steps
1: 90 percent / NaBH4; CeCl3 / methanol / 0 °C
2: H2 / PtO2
3: Et3N
4: NaN3 / dimethylformamide / Heating
5: LiAlH4 / tetrahydrofuran
6: K2CO3
7: 90 percent / NaH / dimethylformamide
8: TBAF / tetrahydrofuran
9: Et3N
10: LiI / tetrahydrofuran
11: Zn; AcOH / ethanol
12: 94 percent / NaBH4 / ethanol
13: bis(tricyclohexylphosphine)benzylideneruthenium(IV)dichlorid
14: H2 / PtO2
15: Bu3P; Py
16: NaH
17: H2O2 / H2O
18: CaCO3 / diphenyl ether / Heating
19: OsO4; NMO / H2O; tetrahydrofuran
20: Py
21: K2CO3 / methanol
22: 61 percent / KOH / methanol
23: 92 percent / Dess-Martin reagent
With
pyridine; potassium hydroxide; sodium tetrahydroborate; osmium(VIII) oxide; lithium aluminium tetrahydride; Grubbs catalyst first generation; sodium azide; N-methyl-2-indolinone; cerium(III) chloride; tributylphosphine; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; sodium hydride; potassium carbonate; Dess-Martin periodane; acetic acid; triethylamine; calcium carbonate; lithium iodide; zinc;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; diphenylether; ethanol; water; N,N-dimethyl-formamide;
1: Reduction / 2: Catalytic hydrogenation / 3: Substitution / 4: Substitution / 5: Reduction / 6: Substitution / 7: Substitution / 8: desilylation / 9: Substitution / 10: Substitution / 11: Reduction / 12: Reduction / 13: Cyclization / 14: Catalytic hydrogenation / 15: Substitution / 16: Substitution / 17: Oxidation / 18: Elimination / 19: hydroxylation / 20: Tosylation / 21: Cyclization / 22: Ring cleavage / 23: Dess-Martin oxidation;
DOI:10.1021/ol006384f
![(2R,3S)-3-Benzyloxy-2-[2-hydroxy-3-(4-oxo-4H-quinazolin-3-yl)-propyl]-piperidine-1-carboxylic acid benzyl ester](/Databaselist/images/loading.webp)
