4-Hydroxyquinazoline

Base Information Edit

Chemical Name:4-Hydroxyquinazoline
CAS No.:491-36-1
Molecular Formula:C8H6N2O
Molecular Weight:146.148
Hs Code.:29335995
Mol file:491-36-1.mol

Synonyms:4(1H)-Quinazolinone(6CI,7CI,8CI,9CI);3,4-Dihydroquinazolin-4-one;4(3H)-Quinazolone;4-Oxo-3,4-dihydroquinazoline;4-Oxoquinazoline;4-Quinazolinol;4-Quinazolinone;4-Quinazolone;NSC 5863;

Suppliers and Price of 4-Hydroxyquinazoline

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
4-HQN
50mg
$ 339.00

Usbiological
4-Hydroxyquinazoline
25g
$ 332.00

TRC
4-Hydroxyquinazoline
10g
$ 60.00

TCI Chemical
4-Hydroxyquinazoline >98.0%(T)
5g
$ 11.00

TCI Chemical
4-Hydroxyquinazoline >98.0%(T)
25g
$ 27.00

SynQuest Laboratories
4(3H)-Quinazolinone
25 g
$ 150.00

Sigma-Aldrich
4-Hydroxyquinazoline 98%
5g
$ 32.70

Medical Isotopes, Inc.
4-Hydroxyquinazoline
2.5 g
$ 620.00

Matrix Scientific
Quinazolin-4(3H)-one
500mg
$ 95.00

Frontier Specialty Chemicals
4-Hydroxyquinazoline 98%
5g
$ 35.00

Total 107 raw suppliers

Chemical Property of 4-Hydroxyquinazoline Edit

Chemical Property:

Appearance/Colour:off-white to light beige crystalline powder
Vapor Pressure:0.000928mmHg at 25°C
Melting Point:216-219 °C(lit.)
Refractive Index:1.666
Boiling Point:303.5 °C at 760 mmHg
PKA:2.69±0.20(Predicted)
Flash Point:137.3 °C
PSA：45.75000
Density:1.31 g/cm³
LogP:0.92310
Storage Temp.:Desiccate at RT
Sensitive.:Hygroscopic
Solubility.:Soluble in DMSO (up to 14 mg/ml) or in Water (up to 1 mg/ml).
Water Solubility.:Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).

Purity/Quality:

98%, ^*data from raw suppliers

4-HQN ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi, Xn
Hazard Codes:Xi,Xn
Statements: 36/37/38-22
Safety Statements: 26-37/39-36/37/39-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Description 4-HQN (491-36-1) is an inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50?= 9.5 μM).1?Displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart.2?4-HQN is anti-inflammatory in LPS-induced endotoxic mice?in vivo; decreases NF-κB and AP-1 activation.3
Uses 4-Hydroxyquinazoline shows anti-microbial and anti-carcinogenic activity as seen in studies due to the quinazoline moiety. 4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.

Technology Process of 4-Hydroxyquinazoline

There total 199 articles about 4-Hydroxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%