Methyl 3-phenylbicyclo[1.1.0]butane-1-carboxylate

Base Information

Chemical Name:Methyl 3-phenylbicyclo[1.1.0]butane-1-carboxylate
CAS No.:30493-96-0
Molecular Formula:C12H12O2
Molecular Weight:188.226
Hs Code.:
DSSTox Substance ID:DTXSID70574809
Wikidata:Q82463977
Mol file:30493-96-0.mol

Synonyms:30493-96-0;Methyl 3-phenylbicyclo[1.1.0]butane-1-carboxylate;SCHEMBL17467927;DTXSID70574809;Methyl3-phenylbicyclo[1.1.0]butane-1-carboxylate

Suppliers and Price of Methyl 3-phenylbicyclo[1.1.0]butane-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3-phenylbicyclo[1.1.0]butane-1-carboxylate

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:188.083729621
Heavy Atom Count:14
Complexity:270

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C12CC1(C2)C3=CC=CC=C3

Technology Process of Methyl 3-phenylbicyclo[1.1.0]butane-1-carboxylate

There total 7 articles about Methyl 3-phenylbicyclo[1.1.0]butane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 36126-39-3
methyl 3-bromo-3-phenylcyclobutane-1-carboxylate

: 30493-96-0
methyl 3-phenylbicyclo<1.1.0>butane-1-carboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; methanol; for 5h; Heating;
DOI:10.1021/ja00311a003

Reference yield:

: 23761-26-4
3-phenyl-3-hydroxycyclobutane-1-carboxylic acid

: 30493-96-0
methyl 3-phenylbicyclo<1.1.0>butanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: TsOH, aq. HCl, CH₂(OMe)2

2: NaH / tetrahydrofuran

With hydrogenchloride; Dimethoxymethane; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran;
DOI:10.1021/ja00730a022

Reference yield:

: 227935-29-7
methyl 3-phenylcyclobutane-1-carboxylate

: 30493-96-0
methyl 3-phenylbicyclo<1.1.0>butane-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: NBS, benzoyl peroxyde / CCl₄ / 1 h / Heating

2: 91 percent / NaH / tetrahydrofuran; methanol / 5 h / Heating

With N-Bromosuccinimide; Perbenzoic acid; sodium hydride; In tetrahydrofuran; methanol; tetrachloromethane;
DOI:10.1021/ja00311a003