3-(Pyrrolidin-1-yl)acrylaldehyde

Base Information

• Chemical Name: 3-(Pyrrolidin-1-yl)acrylaldehyde
• CAS No.: 30545-31-4
• Molecular Formula: C7H11NO
• Molecular Weight: 125.17
• Mol file: 30545-31-4.mol

Synonyms:

Chemical Property of 3-(Pyrrolidin-1-yl)acrylaldehyde

Chemical Property:

• PSA: 20.31000
• LogP: 0.73270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Pyrrolidin-1-yl)acrylaldehyde

There total 1 articles about 3-(Pyrrolidin-1-yl)acrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-prop-2-ynylpyrrolidine N-oxide → pyrrolidine (123-75-1) + 1-(prop-2-yn-1-yl)pyrrolidine (7223-42-9) + N-acryloylpyrrolidine (42104-70-1,31605-88-6) + (E)-3-(pyrrolidin-1-yl)acrylaldehyde (30545-31-4)

Guidance literature:

In tert-butyl alcohol; at 65 - 79 ℃; pH=11; Further Variations:; Solvents; pH-values; Temperatures; Product distribution;

DOI:10.1002/ejoc.200300461

Reference yield:

(E)-3-(pyrrolidin-1-yl)acrylaldehyde (30545-31-4) → 3-(Pyrrolidin-1-yl)prop-2-inal (223761-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Br₂; 2.) Et₃N / 1.) CH₂Cl₂ 0 deg C; 2.) CH₂Cl₂, Et₂O, 0 deg C, 30 min

2: 15 percent / t-BuOK / tetrahydrofuran / 1 h / 0 °C

With potassium tert-butylate; bromine; triethylamine; In tetrahydrofuran;

DOI:10.1002/(SICI)1522-2675(19990310)82:3<326::AID-HLCA326>3.0.CO;2-L

Downstream raw materials:

3-(Pyrrolidin-1-yl)prop-2-inal

Refernces