2-Methoxy-3-nitrothiophene

Base Information

• Chemical Name: 2-Methoxy-3-nitrothiophene
• CAS No.: 30549-14-5
• Molecular Formula: C5H5NO3S
• Molecular Weight: 159.16300
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID60505566
• Nikkaji Number: J418.118B
• Wikidata: Q82360777
• Mol file: 30549-14-5.mol

Synonyms:2-Methoxy-3-nitrothiophene;30549-14-5;Thiophene, 2-methoxy-3-nitro-;SCHEMBL6309949;DTXSID60505566;MFCD16622266;FT-0725790

Chemical Property of 2-Methoxy-3-nitrothiophene

Chemical Property:

• Melting Point: 97-99 °C(Solv: methanol (67-56-1))
• Boiling Point: 284.3±20.0 °C(Predicted)
• PSA: 83.29000
• Density: 1.386±0.06 g/cm3(Predicted)
• LogP: 2.18810
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 158.99901420
• Heavy Atom Count: 10
• Complexity: 135

Purity/Quality:

99%min. ^*data from raw suppliers

2-methoxy-3-nitrothiophene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CS1)[N+](=O)[O-]

Technology Process of 2-Methoxy-3-nitrothiophene

There total 2 articles about 2-Methoxy-3-nitrothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxythiophene (16839-97-7) → 2-methoxy-5-nitrothiophene (30549-16-7) + 2-methoxy-3-nitrothiophene (30549-14-5)

Guidance literature:

With nitric acid; acetic anhydride;

DOI:10.1021/ja01111a027

Reference yield:

2-chloro-3-nitrothiophene (5330-98-3) → 2-methoxy-3-nitrothiophene (30549-14-5)

Guidance literature:

DOI:10.1021/ja01132a004

Reference yield:

2-methoxy-3-nitrothiophene (30549-14-5) + benzyl-methyl-amine (103-67-3) → 2-N-benzylmethylamino-3-nitrothiophene

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; Rate constant;

upstream raw materials:

2-methoxythiophene

2-chloro-3-nitrothiophene