16839-97-7

Basic information

• Product Name: 2-Methoxythiophene
• Synonyms: 2-METHOXYTHIOPHENE;METHYL 2-THIENYL ETHER;Thiophene, 2-methoxy-;2-Methoxythiophene,97%;Methoxythiophene;2-Methoxythiophene,99%;2-Methoxythiophene 97%
• CAS NO: 16839-97-7
• Molecular Formula: C₅H₆OS
• Molecular Weight: 114.17
• EINECS: 240-863-2
• Product Categories: Thiophenes;Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Thiophene Series
• Mol File: 16839-97-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 151-152 °C762 mm Hg(lit.)
• Flash Point: 110 °F
• Appearance: Clear yellow liquid
• Density: 1.133 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.528(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• BRN: 106271
• CAS DataBase Reference: 2-Methoxythiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxythiophene(16839-97-7)
• EPA Substance Registry System: 2-Methoxythiophene(16839-97-7)

Safety Data

• Statements: 10
• Safety Statements: 16
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 16839-97-7(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR YELLOW LIQUID

Uses

2-Methoxythiophene was used in thermal reaction (60°C) of (C5Me5)Rh(PMe3)(Ph)H.

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 3697, 1953 DOI: 10.1021/ja01111a027

General Description

2-Methoxythiophene is a heterocyclic methyl enol ether and its reaction with o-quinone monoimide was studied. The intramolecular and intermolecular geometries of crystals of 2-methoxythiophene were investigated. Kinetics of the hydronium-ion catalysed hydrolysis of 2-methoxythiophene was reported.

InChI:InChI=1/C5H6OS/c1-6-5-3-2-4-7-5/h2-4H,1H3

Upstream product

• 3437-95-4 2-Iodothiophene 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 3354-32-3 2,5-dihydro-2H-2-oxothiophene 
• 1003-09-4 2-bromothiophene 
• 78395-08-1 4-Iodo-2-methoxythiophene 
• 19259-06-4 diiodo-2,4 thiophene 
• 3140-93-0 2,3-dibromothiophen 
• 77998-60-8 (5-Methoxy-thiophen-2-yl)-trimethyl-silane 

Downstream Products

• 31053-55-1 thiophene, 2-methoxy-5-methyl- 
• 57070-77-6 5-bromo-2-methoxythiophene 
• 29212-22-4 5-methoxythiophene-2-carboxylic acid 
• 30549-16-7 2-methoxy-5-nitrothiophene 
• 30549-14-5 2-methoxy-3-nitrothiophene 
• 163928-54-9 5-methoxy-2,2’-bithiophene 
• 492-97-7 2,2'-Bithiophene 
• 144852-97-1 3,3'-dimethoxy-2,2'-bithiophene 
• 77133-30-3 2-methoxy-3,5-dibromothiophene 
• 527-17-3 Duroquinone 
• 882-33-7 diphenyldisulfane 
• 32136-52-0 dimethyl 3-methoxyphthalate 
• 1314904-87-4 5-methoxytiophen-2-sulphonyl chloride 
• 251999-87-8 (E)-p-nitrophenyl 3-(5-methoxy-2-thienyl)acrylate 

Relevant articles and documents

A ligand-free, powerful, and practical method for methoxylation of unactivated aryl bromides by use of the CuCl/HCOOMe/MeONa/MeOH system

A ligand-free, powerful, and practical method for mono and polymethoxylation of unactivated aryl bromides has been developed; CuCl was used as catalyst, HCOOMe as cocatalyst, and methanolic MeONa as both nucleophile and solvent. This eco-friendly procedure is characterized by operational simplicity, inexpensive substrates (unactivated mono to polybromoarenes), full conversion, and direct recovery of pure MeOH.

Facile preparation of thiophene C2-ethers using the Mitsunobu reaction

The preparation of thiophene ethers generally requires forcing conditions thus limiting the choice of alkyl substituent. Herein, we report the first successful generally applicable conditions for the selective O-alkylation of 2(5H)-thiophenone.

2-(substituted-phenyl)amino-imidazoline derivatives

This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where:R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.