Naphthalene, 1-fluoro-4-methyl-

Base Information

• Chemical Name: Naphthalene, 1-fluoro-4-methyl-
• CAS No.: 315-50-4
• Molecular Formula: C11H9F
• Molecular Weight: 160.191
• Mol file: 315-50-4.mol

Synonyms:1-Fluor-4-methylnaphthalin;1-Methyl-4-fluornaphthalin;4-fluoro-1-methylnaphthalene;4-methyl-1-fluoronaphthalene;1-Fluor-4-methyl-naphthalin;1-Fluoro-4-methyl-naphthalene;

Chemical Property of Naphthalene, 1-fluoro-4-methyl-

Chemical Property:

• PSA: 0.00000
• LogP: 3.28730

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-1-methylnaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Naphthalene, 1-fluoro-4-methyl-

There total 7 articles about Naphthalene, 1-fluoro-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

Trimethylboroxine (823-96-1) + 1-fluoro-4-nitronaphthalene (341-92-4) → 4-fluoro-1-methylnaphthalene (315-50-4)

Guidance literature:

With palladium(II) acetylacetonate; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; caesium carbonate; In toluene; at 150 ℃; for 24h;

DOI:10.1039/d0sc01641a

Reference yield:

1-Methylnaphthalene (90-12-0,34475-76-8) → 4-fluoro-1-methylnaphthalene (315-50-4) + 2-fluoro-1-methylnaphthalene (703-47-9) + 2,4-difluoro-1-methylnaphthalene

Guidance literature:

With NFTh; In acetonitrile; at 80 ℃; for 3h; Yield given. Yields of byproduct given;

DOI:10.1246/cl.1996.1077

Reference yield:

4-fluoro-1-naphthoic acid (573-03-5) → 4-fluoro-1-methylnaphthalene (315-50-4)

Guidance literature:

(reduction);

DOI:10.1021/ja00757a010

upstream raw materials:

1-amino-4-methylnaphthalene

4-fluoro-1-naphthoic acid

1-Methylnaphthalene

Trimethylboroxine

Downstream raw materials:

trans-1-<4-Fluor-1-methyl-naphthyl-(2)>-2-(o-iodphenyl)-aethylen

1,4-dimethylnaphthalene