573-03-5 Usage
Uses
Used in Pharmaceutical Industry:
4-FLUORO-1-NAPHTHOIC ACID is used as an inhibitor for Yersinia PTP YopH, a bacterial enzyme, for the development of potential treatments against bacterial infections caused by Yersinia species. Its inhibitory action on YopH contributes to the disruption of bacterial pathogenesis, making it a valuable compound in the fight against antibiotic-resistant bacteria.
Used in Chemical Research:
4-FLUORO-1-NAPHTHOIC ACID, with its extended aromatic system, is used as a research compound in the field of chemistry. It serves as a starting material or intermediate for the synthesis of various complex organic molecules, particularly those with potential applications in pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Drug Development:
4-FLUORO-1-NAPHTHOIC ACID is used as a lead compound in drug development, particularly for the design and synthesis of new inhibitors targeting bacterial enzymes. Its IC50 value, a measure of its potency, has been determined, providing valuable information for further optimization and development of more effective inhibitors against Yersinia PTP YopH and other related enzymes.
Check Digit Verification of cas no
The CAS Registry Mumber 573-03-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,7 and 3 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 573-03:
(5*5)+(4*7)+(3*3)+(2*0)+(1*3)=65
65 % 10 = 5
So 573-03-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H7FO2/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H,(H,13,14)/p-1
573-03-5Relevant academic research and scientific papers
Preparation of a series of substituted fluoromethylnaphthalenes
Dixon, Elisabeth A.,Fischer, Alfred,Robinson, Frank P.
, p. 2629 - 2641 (2007/10/02)
A series of 22 3- and 4-substituted 1-fluoromethylnaphthalenes have been synthesized.Details of practical procedures for the preparation of all intermediates are described, and physical properties for all of the substituted naphthalenes synthesized, and spectral parameters for 51 previously unknown compounds, are given.
Kinetics of Base-catalysed Iodination of Substituted Acetonaphthones
Ananthakrishnanadar, P.,Gnanasekaran, C.
, p. 646 - 649 (2007/10/02)
Kinetics of iodination of 6-substituted 2-acetonaphthones and of 4-substituted 1-acetonaphthones in 20percent pyridine-20percent methanol-60percent water (v/v) have been followed at three temperatures.The Hammett equation applies very well to these reactions.The rate constants for various heterocyclic base-catalysed iodination of acetophenone and of 1- and 2-acetonaphthones in 60percent (v/v) methanol-water solvent have been correlated with pKa values of the conjugate acids of the heterocyclic bases via the Broensted equation giving β values of 0.88, 1.01 and 0.92 for acetophenone, 1-acetonaphthone and 2-acetonaphthone respectively.The influence of solvent on the rates of pyridine-catalysed iodination of acetophenone and of 1- and 2-acetonaphthones has also been studied.
