4-(Benzo[d]oxazol-2-yl)-2-Methoxyphenol

Base Information

• Chemical Name: 4-(Benzo[d]oxazol-2-yl)-2-Methoxyphenol
• CAS No.: 3164-07-6
• Molecular Formula: C14H11NO3
• Molecular Weight: 241.246
• Mol file: 3164-07-6.mol

Synonyms:2-(4'-amino-3'-bromophenyl)benzothiazole;2-(4-Hydroxy-3-methoxy-phenyl)-benzoxazol;4-benzooxazol-2-yl-2-methoxy-phenol;4-benzoxazol-2-yl-2-methoxy-phenol;4-(1,3-benzothiazole-2-yl)-2-bromoaniline;2-(4'-hydroxy-3'-methoxyphenyl)benzothiazole;4-(Benzo[d]oxazol-2-yl)-2-methoxyphenol;

Chemical Property of 4-(Benzo[d]oxazol-2-yl)-2-Methoxyphenol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 387.653oC at 760 mmHg
• Flash Point: 188.246oC
• PSA: 55.49000
• Density: 1.288g/cm3
• LogP: 3.20900
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

4-(Benzo[d]oxazol-2-yl)-2-methoxyphenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Benzo[d]oxazol-2-yl)-2-Methoxyphenol

There total 4 articles about 4-(Benzo[d]oxazol-2-yl)-2-Methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-methoxy-4-hydroxybenzoic acid (121-34-6) + 2-amino-phenol (95-55-6) → 4-(benzo[d]oxazol-2?-yl)-2-methoxyphenol (3164-07-6)

Guidance literature:

With trimethylsilylphosphate; at 180 ℃; for 0.5h;

DOI:10.1016/j.bmc.2003.10.021

Reference yield: 95.0%

2-[4-(benzyloxy)-3-methoxyphenyl]-1,3-benzoxazole (1236771-62-2) → 4-(benzo[d]oxazol-2?-yl)-2-methoxyphenol (3164-07-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2010.05.007

Reference yield: 80.0%

N**2-(3-methoxy-4-hydroxybenzylidene)aminophenol (51821-39-7) → 4-(benzo[d]oxazol-2?-yl)-2-methoxyphenol (3164-07-6)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In methanol; at 20 ℃; for 0.166667h;

DOI:10.1016/j.tet.2015.06.073

upstream raw materials:

3-methoxy-4-hydroxybenzoic acid

2-amino-phenol

2-[4-(benzyloxy)-3-methoxyphenyl]-1,3-benzoxazole

N**2-(3-methoxy-4-hydroxybenzylidene)aminophenol

Downstream raw materials:

2-[4-(5-bromopentyloxy)-3-methoxyphenyl]-1,3-benzoxazole

(2S)-N-{4-(N-[4-(1,3-benzoxazole-2-yl)-2-methoxyphenoxy]pentyl)oxy-5-methoxy-2-nitrobenzoyl}-pyrrolidine-2-carboxaldehyde diethylthioacetal

4-(1,3-benzoxazol-2-yl)-2-methoxyphenyl trifluoromethanesulfonate

Refernces

• 1、 -. "ALIGNMENT COMPOUNDS". Paragraph 0141. . Retrieved 2017/01/31.
• 2、 Wang, Bowei,Vernier, Jean-Michel,Rao, Sara,Chung, Janice,Anderson, Jeffery J.,Brodkin, Jesse D.,Jiang, Xiaohui,Gardner, Michael F.,Yang, Xiaoqing,Munoz, Benito. "Discovery of novel modulators of metabotropic glutamate receptor subtype-5". . p. 17 - 21. Retrieved 2007/10/03.