4-Amino-1-benzyl-2-methylpiperidine

Base Information

• Chemical Name: 4-Amino-1-benzyl-2-methylpiperidine
• CAS No.: 321345-30-6
• Molecular Formula: C₁₃H₂₀N₂
• Molecular Weight: 204.315
• Hs Code.: 2933399090
• Mol file: 321345-30-6.mol

Synonyms:1-benzyl-2-methylpiperidin-4-amine;

Chemical Property of 4-Amino-1-benzyl-2-methylpiperidine

Chemical Property:

• Vapor Pressure: 0.00198mmHg at 25°C
• Boiling Point: 291.1oC at 760 mmHg
• Flash Point: 121oC
• PSA: 29.26000
• Density: 1.004g/cm3
• LogP: 2.63640
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl-2-methylpiperidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Amino-1-benzyl-2-methylpiperidine

There total 4 articles about 4-Amino-1-benzyl-2-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-(benzylamino)butanoate (6335-80-4) → (1)-4-amino-1-benzyl-2-methylpiperidine (321345-30-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 32 h / 150 °C

2: sodium hydride / ethanol; toluene / 15 h / 20 °C

3: hydrogenchloride / water / 15 h / 100 °C

4: ammonium acetate; sodium cyanoborohydride / methanol / 16 h / 20 °C / Molecular sieve; Inert atmosphere

With hydrogenchloride; ammonium acetate; sodium hydride; sodium cyanoborohydride; In methanol; ethanol; water; toluene;

Reference yield:

C17H25NO4 → (1)-4-amino-1-benzyl-2-methylpiperidine (321345-30-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / ethanol; toluene / 15 h / 20 °C

2: hydrogenchloride / water / 15 h / 100 °C

3: ammonium acetate; sodium cyanoborohydride / methanol / 16 h / 20 °C / Molecular sieve; Inert atmosphere

With hydrogenchloride; ammonium acetate; sodium hydride; sodium cyanoborohydride; In methanol; ethanol; water; toluene;

Reference yield:

methyl 1-benzyl-6-methyl-4-oxopiperidine-3-carboxylate → (1)-4-amino-1-benzyl-2-methylpiperidine (321345-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / 15 h / 100 °C

2: ammonium acetate; sodium cyanoborohydride / methanol / 16 h / 20 °C / Molecular sieve; Inert atmosphere

With hydrogenchloride; ammonium acetate; sodium cyanoborohydride; In methanol; water;

upstream raw materials:

benzylamine

ethyl 3-(benzylamino)butanoate