1H-Imidazo[1,2-a]imidazol-2(3H)-one, 5-[[4-(acetyloxy)butyl]sulfonyl]-3-[(4-bromophenyl)methyl]-1-(3,5-dichloro phenyl)-3-methyl-, (3R)-

Base Information

Chemical Name:1H-Imidazo[1,2-a]imidazol-2(3H)-one, 5-[[4-(acetyloxy)butyl]sulfonyl]-3-[(4-bromophenyl)methyl]-1-(3,5-dichloro phenyl)-3-methyl-, (3R)-
CAS No.:321723-77-7
Molecular Formula:C25H24BrCl2N3O5S
Molecular Weight:629.359
Hs Code.:

Synonyms:

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Chemical Property of 1H-Imidazo[1,2-a]imidazol-2(3H)-one, 5-[[4-(acetyloxy)butyl]sulfonyl]-3-[(4-bromophenyl)methyl]-1-(3,5-dichloro phenyl)-3-methyl-, (3R)-

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MSDS Files:: SDS file from LookChem

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Technology Process of 1H-Imidazo[1,2-a]imidazol-2(3H)-one, 5-[[4-(acetyloxy)butyl]sulfonyl]-3-[(4-bromophenyl)methyl]-1-(3,5-dichloro phenyl)-3-methyl-, (3R)-

There total 2 articles about 1H-Imidazo[1,2-a]imidazol-2(3H)-one, 5-[[4-(acetyloxy)butyl]sulfonyl]-3-[(4-bromophenyl)methyl]-1-(3,5-dichloro phenyl)-3-methyl-, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4753-59-7
4-Bromobutyl acetate

: 321656-73-9
(R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1H-imidazo[1,2-α]imidazol-2-one

: 321723-77-7
acetic acid 4-[5-(4-bromo-benzyl)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-butyl ester

Guidance literature:: (R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl-1H-imidazo[1,2-α]imidazol-2-one; With cyclopentylmagnesium bromide; In tetrahydrofuran; at -40 ℃; for 0.666667h;

With sulfur dioxide; In tetrahydrofuran; at -40 - 20 ℃; for 1.25h;

4-Bromobutyl acetate; With potassium carbonate; In N,N-dimethyl-formamide; at 70 - 80 ℃;
DOI:10.1021/jm049657b

Reference yield:

: 321656-72-8
(R)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1-hydroimidazo[1,2-a]imidazol-2-one

: 321723-77-7
acetic acid 4-[5-(4-bromo-benzyl)-7-(3,5-dichloro-phenyl)-5-methyl-6-oxo-6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-iodosuccinimide; pyridinium p-toluenesulfonate / CH₂Cl₂ / 0 °C

2.1: cyclopentylmagnesium bromide / tetrahydrofuran / 0.67 h / -40 °C

2.2: SO₂ / tetrahydrofuran / 1.25 h / -40 - 20 °C

2.3: potassium carbonate / dimethylformamide / 70 - 80 °C

With N-iodo-succinimide; pyridinium p-toluenesulfonate; cyclopentylmagnesium bromide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm049657b