4753-59-7

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromobutyl acetate is used as a synthetic intermediate for the production of 9-alkylguanine derivatives, which are significant in the development of potential therapeutic agents. Its chemical properties allow for the creation of various pharmaceutical compounds with different applications in medicine.
Used in Chemical Synthesis:
4-Bromobutyl acetate is used as a reagent in chemical synthesis processes, particularly for the creation of complex organic molecules. Its versatility and stability make it a valuable component in the synthesis of a wide array of chemical products.

Synthesis Reference(s)

The Journal of Organic Chemistry, 40, p. 3571, 1975 DOI: 10.1021/jo00912a022

InChI:InChI=1/C6H11BrO2/c1-6(8)9-5-3-2-4-7/h2-5H2,1H3

Upstream product

• 109-99-9 tetrahydrofuran 
• 506-96-7 Acetyl bromide 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 4469-25-4 2-methyl-[1,3]dioxepane 
• 42023-34-7 4-bromobutyl phosphite 
• 110-52-1 1,4-dibromo-butane 
• 33036-62-3 4-Bromo-1-butanol 
• 57-13-6 urea 
• 26976-89-6 5-(4-methoxyphenyl)furan-2(5H)-one 
• 21963-26-8 2-nonen-4-olide 
• 35435-68-8 4-acetoxy-1-butanol 
• 53209-91-9 4-Perchlorato-butylacetat 

Downstream Products

• 4672-11-1 4-piperidin-1-yl-butan-1-ol 
• 5835-79-0 4-(1-hydroxypropyl)morpholine 
• 107698-71-5 ethanoic acid-3-(ethanoic acid-butyr-4-yl ester)-5,6,7,9-tetrahydro-5-(1-oxoethyl)-9-oxo-3H-imidazo<1,2-a>purine-6,7-diyl ester 
• 107698-72-6 ethanoic acid-3-(ethanoic acid-butyr-4-yl ester)-5,6,7,9-tetrahydro-5-(1-oxoethyl)-9-oxo-1H-imidazo<1,2-a>purine-6,7-diyl ester 
• 142668-42-6 Acetic acid 4-[5-(4-methyl-benzyloxymethyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-butyl ester 
• 142668-35-7 Acetic acid 4-[3-(4-acetoxy-butyl)-5-(4-methyl-benzyloxymethyl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyl ester 
• 142668-43-7 Acetic acid 4-[2,4-dioxo-5-(1-phenyl-ethoxymethyl)-3,4-dihydro-2H-pyrimidin-1-yl]-butyl ester 
• 142668-36-8 Acetic acid 4-[3-(4-acetoxy-butyl)-2,6-dioxo-5-(1-phenyl-ethoxymethyl)-3,6-dihydro-2H-pyrimidin-1-yl]-butyl ester 
• 373-09-1 4-fluorobutyl acetate 
• 121824-90-6 3-fluorobutyl acetate 
• 33036-62-3 4-Bromo-1-butanol 
• 14970-83-3 4-Mercapto-1-butanol 
• 142668-40-4 Acetic acid 4-(5-benzyloxymethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-butyl ester 
• 142668-33-5 Acetic acid 4-[3-(4-acetoxy-butyl)-5-benzyloxymethyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyl ester 

Relevant academic research and scientific papers

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Second-coordination sphere effects on the reactivities of Hoveyda-Grubbs-type catalysts: A ligand exchange study using phenolic moiety-functionalized ligands

The Hoveyda-Grubbs (HG) second-generation catalyst (HG-II), a Ru complex with a 2-isopropoxybenzylidene ligand, is extensively used for olefin metathesis, the rearrangement of carbon-carbon double bonds. A well-known strategy to control its complex reactivity is to modify the phenyl ring in the ligand, thereby directly influencing the coordination of the phenolic oxygen to the metal center. We, herein, report that a functional group attached to the phenolic moiety in the 2-alkoxybenzylidene ligand can indirectly affect the reactivities of HG-type complexes. In this work, the ligand exchange reactions between HG-II and phenolic moiety-modified 2-alkoxybenzylidene ligands are useful for evaluating the structural effects of the ligands. Specifically, an ethylene amide or an ester group at the terminal phenolic moiety in the benzylidene ligand was found to influence the relative stabilities of HG-type complexes compared to that of the HG-II complex. The structural analyses proved that the observed effects of the functional groups on the complex stabilities originate from the interactions with a chlorido ligand in HG-type complexes without changes in coordination fashions at the metal centers. It was found that the outer-sphere interactions also influence the catalytic activities of HG-type complexes, namely, the properties of HG-type complexes can be controlled by outer-sphere structural factors toward the metal center (i.e., "the second-coordination sphere effect"). In the design of functionalized HG-type complexes, the outer-sphere structural effects need to be considered in addition to the optimization of the metal coordination site.

METHOD FOR PREPARING 4-ISOPROPYLAMINO-1-BUTANOL

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Novel ibuprofen prodrugs with improved pharmacokinetics and non-ulcerogenic potential

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