4753-59-7Relevant articles and documents
Aliphatic hyperbranched polyester: A new building block in the construction of multifunctional nanoparticles and nanocomposites
Santra, Santimukul,Kaittanis, Charalambos,Perez, J. Manuel
, p. 5364 - 5373 (2010)
Herein we report the design and synthesis of multifunctional hyperbranched polyester-based nanoparticles and nanocomposites with properties ranging from magnetic, fluorescence, antioxidant and X-ray contrast. The fabrication of these nanostructures was achieved using a novel aliphatic and biodegradable hyperbranched polyester (HBPE) synthesized from readily available diethyl malonate. The polymer's globular structure with functional surface carboxylic groups and hydrophobic cavities residing in the polymer's interior allows for the formation of multifunctional polymeric nanoparticles, which are able to encapsulate a diversity of hydrophobic cargos. Via simple surface chemistry modifications, the surface carboxylic acid groups were modified to yield nanoparticles with a variety of surface functionalizations, such as amino, azide and propargyl groups, which mediated the conjugation of small molecules. This capability achieved the engineering of the HBPE nanoparticle surface for specific cell internalization studies and the formation of nanoparticle assemblies for the creation of novel nanocomposites that retained, and in some cases enhanced, the properties of the parental nanoparticle building blocks. Considering these results, the HBPE polymer, nanoparticles and composites should be ideal for biomedical, pharmaceutical, nanophotonics applications.
Second-coordination sphere effects on the reactivities of Hoveyda-Grubbs-type catalysts: A ligand exchange study using phenolic moiety-functionalized ligands
Akiyama, Naoki,Goshima, Kenta,Hirota, Shun,Jatmika, Catur,Matsuo, Takashi,Wakabayashi, Kazumo
supporting information, p. 11618 - 11627 (2020/09/09)
The Hoveyda-Grubbs (HG) second-generation catalyst (HG-II), a Ru complex with a 2-isopropoxybenzylidene ligand, is extensively used for olefin metathesis, the rearrangement of carbon-carbon double bonds. A well-known strategy to control its complex reactivity is to modify the phenyl ring in the ligand, thereby directly influencing the coordination of the phenolic oxygen to the metal center. We, herein, report that a functional group attached to the phenolic moiety in the 2-alkoxybenzylidene ligand can indirectly affect the reactivities of HG-type complexes. In this work, the ligand exchange reactions between HG-II and phenolic moiety-modified 2-alkoxybenzylidene ligands are useful for evaluating the structural effects of the ligands. Specifically, an ethylene amide or an ester group at the terminal phenolic moiety in the benzylidene ligand was found to influence the relative stabilities of HG-type complexes compared to that of the HG-II complex. The structural analyses proved that the observed effects of the functional groups on the complex stabilities originate from the interactions with a chlorido ligand in HG-type complexes without changes in coordination fashions at the metal centers. It was found that the outer-sphere interactions also influence the catalytic activities of HG-type complexes, namely, the properties of HG-type complexes can be controlled by outer-sphere structural factors toward the metal center (i.e., "the second-coordination sphere effect"). In the design of functionalized HG-type complexes, the outer-sphere structural effects need to be considered in addition to the optimization of the metal coordination site.
Preparation method of 4-halobutyl acetate
-
Paragraph 0073-0080; 0087-0088; 0091, (2018/09/20)
The invention discloses a preparation method of 4-halobutyl acetate, relates to the preparation method of acetate and aims to solve the technical problems that in an existing method for preparing the4-halobutyl acetate, the reaction time is long, the reaction temperature is high, the cost is high, a toxic reagent is used, the operation is complicated, and the yield is low. The preparation methodcomprises the following steps: mixing and stirring urea, tetrahydrofuran and acetyl halide, naturally cooling to room temperature, adding distilled water, regulating pH (Potential of Hydrogen) to be neutral, carrying out suction filtration, extracting, drying, filtering, and distilling. The 4-halobutyl acetate prepared by the invention structurally contains an ester group and chain end halogen andis a multi-purpose polyfunctional compound. The 4-halobutyl acetate prepared by the invention is prepared from corresponding acyl halide and cyclic ether under catalysis of the urea, and the preparation method is bran-new. A solid byproduct of the preparation method is acyl urea. The preparation method disclosed by the invention has the advantages of simple operation, low cost, safety and high efficiency, environment friendliness and the like.
