4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorobenzoic acid

Base Information

Chemical Name:4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorobenzoic acid
CAS No.:324789-22-2
Molecular Formula:C11H9FN4O4
Molecular Weight:280.215
Hs Code.:
DSSTox Substance ID:DTXSID60514173
Wikidata:Q82374349
Mol file:324789-22-2.mol

Synonyms:324789-22-2;4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorobenzoic acid;SCHEMBL14023960;DTXSID60514173;IVPFWEFMGOMJGG-ZETCQYMHSA-N;4-(5(r)-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluorobenzoic acid

Suppliers and Price of 4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorobenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorobenzoic acid

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:280.06078294
Heavy Atom Count:20
Complexity:454

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OC(=O)N1C2=CC(=C(C=C2)C(=O)O)F)CN=[N+]=[N-]
Isomeric SMILES:C1[C@@H](OC(=O)N1C2=CC(=C(C=C2)C(=O)O)F)CN=[N+]=[N-]

Technology Process of 4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorobenzoic acid

There total 2 articles about 4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

: 324789-00-6
tert-butyl 4-(5-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluoro-benzoate

: 324789-22-2
4-(5(R)-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluorobenzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 324788-99-0
5-(R)-hydroxymethyl-3-[4'-tert-butoxycarbonyl-3'-fluorophenyl]oxazolidine-2-one

: 324789-22-2
4-(5(R)-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 4 h / 60 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With sodium azide; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield: 99.0%

: 324789-22-2
4-(5(R)-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluorobenzoic acid

: 870-46-2
t-butoxycarbonylhydrazine

: 581063-77-6
N'-[4-(5(R)-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluorobenzoyl]-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:: 4-(5(R)-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluorobenzoic acid; With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.333333h;

t-butoxycarbonylhydrazine; In DMF (N,N-dimethyl-formamide); at 20 ℃;