5,6-Dimethoxy-1-methyl-1,2,3,8,9,9a-hexahydro-7H-benzo(de)quinolin-7-one

Base Information

Chemical Name:5,6-Dimethoxy-1-methyl-1,2,3,8,9,9a-hexahydro-7H-benzo(de)quinolin-7-one
CAS No.:35690-87-0
Molecular Formula:C15H19NO3
Molecular Weight:261.321
Hs Code.:
NSC Number:187775

Synonyms:35690-87-0;5,6-Dimethoxy-1-methyl-1,2,3,8,9,9a-hexahydro-7H-benzo(de)quinolin-7-one;5,6-dimethoxy-1-methyl-1,2,3,8,9,9a-hexahydro-7h-benzo[de]quinolin-7-one;5,6-Dimethoxy-1-methyl-2,3,9,9a-tetrahydro-1H-benzo[de]quinolin-7(8H)-one;BRN 1542353;NSC187775;7H-Benzo(de)quinolin-7-one, 1,2,3,8,9,9a-hexahydro-5,6-dimethoxy-1-methyl-;2,3,7,8,9,9a-Hexahydro-5,6-dimethoxy-1-methyl-1H-benzo(de)chinolin-7-on [German];SCHEMBL10639161;2,3,7,8,9,9a-Hexahydro-5,6-dimethoxy-1-methyl-1H-benzo(de)chinolin-7-on;NSC 187775;NSC-187775

Suppliers and Price of 5,6-Dimethoxy-1-methyl-1,2,3,8,9,9a-hexahydro-7H-benzo(de)quinolin-7-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 5,6-Dimethoxy-1-methyl-1,2,3,8,9,9a-hexahydro-7H-benzo(de)quinolin-7-one

Chemical Property:

Vapor Pressure:4.46E-07mmHg at 25°C
Boiling Point:414.4°Cat760mmHg
Flash Point:204.4°C
Density:1.169g/cm³
XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:261.13649347
Heavy Atom Count:19
Complexity:359

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC2=CC(=C(C3=C2C1CCC3=O)OC)OC

Technology Process of 5,6-Dimethoxy-1-methyl-1,2,3,8,9,9a-hexahydro-7H-benzo(de)quinolin-7-one

There total 1 articles about 5,6-Dimethoxy-1-methyl-1,2,3,8,9,9a-hexahydro-7H-benzo(de)quinolin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35690-87-0
1,2,3,8,9,9a-hexahydro-5,6-dimethoxy-1-methyl-7H-benzoquinolin-7-one

Guidance literature:: Ester (9*HCl), Oleum;
DOI:10.1002/hlca.19730560219

Reference yield:

: 35690-87-0
1,2,3,8,9,9a-hexahydro-5,6-dimethoxy-1-methyl-7H-benzoquinolin-7-one

: 5630-11-5,139341-79-0,139341-81-4,872418-54-7
(+/-)-glaucine

Guidance literature:: Multi-step reaction with 4 steps

1: H₂O; methanol / 16 h / Ambient temperature

2: 1.) NaH / 1.) DME, 0 deg C, 2.) DME, reflux, 10 min

3: 38 percent / N-bromosuccinimide (NBS), AcOH / H₂O; acetonitrile / 2 h / 0 °C

4: 71 percent / methanol / 3 h / Ambient temperature

With N-Bromosuccinimide; sodium hydride; acetic acid; In methanol; water; acetonitrile;
DOI:10.1248/cpb.41.481

Reference yield:

: 35690-87-0
1,2,3,8,9,9a-hexahydro-5,6-dimethoxy-1-methyl-7H-benzoquinolin-7-one

: 345938-74-1
5,6-dimethoxy-1-methyl-8-phenyl-2,3,7,8,9,9a-hexahydro-1H-benzoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) lithium di-isopropylamide / 1.) THF, hexane, 0.5 h, 2.) 3 h

2: 0.17 g / K, MeOH / 0.5 h / Heating

3: 0.7 g / EtOH / Raney nickel / 0.5 h / Heating

4: 0.2 g / zinc amalgam, HCl / ethanol / 0.67 h / Heating

With hydrogenchloride; methanol; amalgamated zinc; ethanol; lithium diisopropyl amide; nickel; In ethanol;
DOI:10.1039/P19830000909