Alprenolol

Base Information Edit

Chemical Name:Alprenolol
CAS No.:13655-52-2
Molecular Formula:C₁₅H₂₃NO₂
Molecular Weight:249.353
Hs Code.:
European Community (EC) Number:237-140-9
UNII:877K5MQ27W
DSSTox Substance ID:DTXSID0045127
Nikkaji Number:J8.133G
Wikipedia:Alprenolol
Wikidata:Q201370
NCI Thesaurus Code:C81653
Pharos Ligand ID:15BXHYMY5XH9
Metabolomics Workbench ID:43142
ChEMBL ID:CHEMBL266195
Mol file:13655-52-2.mol

Synonyms:2-Propanol,1-(o-allylphenoxy)-3-(isopropylamino)- (8CI); 2-Propanol,1-[(1-methylethyl)amino]-3-[2-(2-propenyl)phenoxy]- (9CI); (RS)-Alprenolol; (?à)-Alprenolol;1-(o-Allylphenoxy)-3-(isopropylamino)-2-propanol;1-Isopropylamino-3-(2-allyl)phenoxypropan-2-ol; Alpheprol; Alprenolol;dl-Alprenolol

Suppliers and Price of Alprenolol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Alprenolol >98%
1 g
$ 700.00

ChemScene
Alprenolol 99.87%
100mg
$ 120.00

ChemScene
Alprenolol 99.87%
50mg
$ 72.00

Cayman Chemical
Alprenolol ≥98%
25mg
$ 45.00

Cayman Chemical
Alprenolol ≥98%
50mg
$ 68.00

Cayman Chemical
Alprenolol ≥98%
100mg
$ 108.00

Biosynth Carbosynth
Alprenolol
10 mg
$ 100.00

Biosynth Carbosynth
Alprenolol
5 mg
$ 60.00

Biosynth Carbosynth
Alprenolol
100 mg
$ 350.00

Biosynth Carbosynth
Alprenolol
50 mg
$ 225.00

Total 46 raw suppliers

Chemical Property of Alprenolol Edit

Chemical Property:

Vapor Pressure:1.46E-06mmHg at 25°C
Melting Point:57.5°C
Refractive Index:1.5250 (estimate)
Boiling Point:383.4°Cat760mmHg
PKA:pKa 9.63 (Uncertain)
Flash Point:185.7°C
PSA：41.49000
Density:1.007g/cm³
LogP:2.54370
Water Solubility.:366.9mg/L(22.5 oC)
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:249.172878976
Heavy Atom Count:18
Complexity:231

Purity/Quality:

99%, ^*data from raw suppliers

Alprenolol >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 23/24/25-43
Safety Statements: 36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Chemical Classes:Other Uses -> Pharmaceuticals
Canonical SMILES:CC(C)NCC(COC1=CC=CC=C1CC=C)O
Description Occupational cases of contact dermatitis caused by exposure to alprenolol have been reported within the pharmaceutical industry.
Uses Antiadrenergic (β-receptor).
Therapeutic Function Beta-adrenergic blocker

Technology Process of Alprenolol

There total 4 articles about Alprenolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: cyclopropanecarboxylic acid 2-(2-allyl-phenoxy)-1-(isopropylamino-methyl)-ethyl ester

: 13655-52-2,23846-70-0,23846-71-1,23846-72-2
alprenolol

: 1759-53-1
cyclopropanecarboxylic acid

Guidance literature:: With water; at 37 ℃; pH=1 - 12; Further Variations:; Reagents; Kinetics;
DOI:10.1023/A:1016204602471

Reference yield:

: 1745-81-9
o-Allylphenol

: 13655-52-2,23846-70-0,23846-71-1,23846-72-2
alprenolol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; tetrabutyl-ammonium chloride / water / 1 h / 45 °C / Flow reactor

2: ethanol; toluene / 0.33 h / 120 °C / 3900.39 Torr / Flow reactor

With tetrabutyl-ammonium chloride; sodium hydroxide; In ethanol; water; toluene;
DOI:10.1039/c5cc06093a