Technology Process of 6-Heptenal, 3,5-dimethoxy-2,4-dimethyl-7-phenyl-, (2R,3R,4R,5S,6E)-
There total 38 articles about 6-Heptenal, 3,5-dimethoxy-2,4-dimethyl-7-phenyl-, (2R,3R,4R,5S,6E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 0.666667h;
Inert atmosphere;
DOI:10.1021/jo301210f
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 99 percent / TBAF / tetrahydrofuran / 16 h / 25 °C
2: Dess-Martin periodinane / CH2Cl2 / 0.25 h / 20 °C
With
tetrabutyl ammonium fluoride; Dess-Martin periodane;
In
tetrahydrofuran; dichloromethane;
2: Dess-Martin oxidation;
DOI:10.1021/jo047732k
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 70 percent / CH2Cl2 / 0.17 h / 0 °C
2: 85 percent / diisobutylaluminum hydride / CH2Cl2; toluene / 0.5 h / -78 °C
3: 82 percent / imidazole / tetrahydrofuran / 1 h / 0 - 20 °C
4: 88 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 4 h / 0 - 20 °C
5: 89 percent / camphorsulfonic acid / methanol; CH2Cl2 / 1 h / 0 - 20 °C
6: 93 percent / tert-butyl hydroperoxide; (i-PrO)4Ti; (-)-diisopropyl tartrate / CH2Cl2; toluene / 1 h / -20 °C
7: 86 percent / CuI / diethyl ether / 2 h / -20 °C
8: imidazole / tetrahydrofuran / 0 - 20 °C
9: NaH; tetrabutylammonium iodide / tetrahydrofuran / 0 - 20 °C
10: camphorsulfonic acid / CH2Cl2; methanol / 0 - 20 °C
11: 96 percent / DMSO; Et3N; SO3*py / CH2Cl2 / 0.33 h
With
1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; copper(l) iodide; (-)-diisopropyl tartrate; pyridine-SO3 complex; camphor-10-sulfonic acid; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
6: Sharpless epoxidation;
DOI:10.1016/S0040-4020(01)00940-1
