1-(4-Ethoxy-3-formylphenylsulfonyl)-4-methylpiperazine

Base Information

Chemical Name:1-(4-Ethoxy-3-formylphenylsulfonyl)-4-methylpiperazine
CAS No.:332374-42-2
Molecular Formula:C14H20N2O4S
Molecular Weight:312.39
Hs Code.:
European Community (EC) Number:920-283-2,641-937-0
DSSTox Substance ID:DTXSID30431681
Nikkaji Number:J1.647.235B
Wikidata:Q82245629

Synonyms:332374-42-2;1-(4-ethoxy-3-formylphenylsulfonyl)-4-methylpiperazine;2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylbenzaldehyde;2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl)]-benzaldehyde;2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]benzaldehyde;2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)benzaldehyde;2-ETHOXY-5-(4-METHYLPIPERAZINE-1-SULFONYL)BENZALDEHYDE (1-[(4-ETHOXY-3-FORMYLPHENYL)SULFONYL]-4-METHYLPIPERAZINE);2-Ethoxy-5-(4-methylpiperazine-1-sulfonyl)benzaldehyde;1-[(4-Ethoxy-3-formylphenyl)sulfonyl]-4-methylpiperazine;SCHEMBL4264787;DTXSID30431681;AMY39052;STL453043;CS-0166509;2-Ethoxy-5-[(4-methylpiperazino)sulfonyl]benzaldehyde;2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)benzaldehyde? (Sildenafil Impurity

Suppliers and Price of 1-(4-Ethoxy-3-formylphenylsulfonyl)-4-methylpiperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of 1-(4-Ethoxy-3-formylphenylsulfonyl)-4-methylpiperazine

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:312.11437830
Heavy Atom Count:21
Complexity:440

Purity/Quality:: 99.9% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=C(C=C(C=C1)S(=O)(=O)N2CCN(CC2)C)C=O

Technology Process of 1-(4-Ethoxy-3-formylphenylsulfonyl)-4-methylpiperazine

There total 5 articles about 1-(4-Ethoxy-3-formylphenylsulfonyl)-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 109-01-3
1-methyl-piperazine

: 2-ethoxy-5-chlorosulfonylbenzaldehyde

: 332374-42-2
2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)benzaldehyde

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1002/ardp.201700354

Reference yield: 47.0%

: 1-(4-ethoxy-3-hydroxymethylphenylsulfonyl)-4-methylpiperazine

: 332374-42-2
2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)benzaldehyde

Guidance literature:: With manganese dioxide;

Reference yield:

: 90-02-8
salicylaldehyde

: 332374-42-2
2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water

2: ammonium chloride / ethanol

3: chlorosulfonic acid / 0 - 5 °C

4: triethylamine / dichloromethane

With chlorosulfonic acid; ammonium chloride; triethylamine; sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1002/ardp.201700354