1H-Imidazole, 2,2'-[2-(diphenylphosphino)ethylidene]bis[1-methyl-

Base Information

Chemical Name:1H-Imidazole, 2,2'-[2-(diphenylphosphino)ethylidene]bis[1-methyl-
CAS No.:332941-36-3
Molecular Formula:C₂₂H₂₃N₄P
Molecular Weight:374.425
Hs Code.:
DSSTox Substance ID:DTXSID60476540
Nikkaji Number:J1.398.236H
Wikidata:Q82308009

Synonyms:332941-36-3;1H-Imidazole, 2,2'-[2-(diphenylphosphino)ethylidene]bis[1-methyl-;DTXSID60476540

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Imidazole, 2,2'-[2-(diphenylphosphino)ethylidene]bis[1-methyl-

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:374.16603375
Heavy Atom Count:27
Complexity:412

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=CN=C1C(CP(C2=CC=CC=C2)C3=CC=CC=C3)C4=NC=CN4C

Technology Process of 1H-Imidazole, 2,2'-[2-(diphenylphosphino)ethylidene]bis[1-methyl-

There total 2 articles about 1H-Imidazole, 2,2'-[2-(diphenylphosphino)ethylidene]bis[1-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 829-85-6
diphenylphosphane

: 332941-36-3
2-[2-(Diphenylphosphino)-1-(1-methyl-1H-imidazol-2-yl)ethyl]-1-methyl-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / n-Bu₄NCl hydrate; aq. KOH / toluene / 14 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -80 - -45 °C

2.2: 85 percent / tetrahydrofuran; hexane / -70 - 20 °C

With potassium hydroxide; n-butyllithium; tetrabutyl-ammonium chloride; In tetrahydrofuran; hexane; toluene;
DOI:10.1055/s-2001-12351

Reference yield:

: 62366-40-9
bis(N-methylimidazol-2-yl)ketone

: 332941-36-3
2-[2-(Diphenylphosphino)-1-(1-methyl-1H-imidazol-2-yl)ethyl]-1-methyl-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 83 percent / KOH; hydrazine hydrate / 4 h / 120 - 150 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -80 - -45 °C

2.2: 85 percent / tetrahydrofuran; hexane / -70 - 20 °C

With potassium hydroxide; n-butyllithium; hydrazine hydrate; In tetrahydrofuran; hexane;
DOI:10.1055/s-2001-12351

Reference yield: 90.0%

: chloromethyl(1,5-cyclooctadiene)palladium(II)

: 332941-36-3
2-[2-(Diphenylphosphino)-1-(1-methyl-1H-imidazol-2-yl)ethyl]-1-methyl-1H-imidazole

: 396112-13-3,307948-94-3
[PdCl(CH3)(σ2(N,P)-2-[2-(diphenylphosphino)-1-(1-methylimidazol-2-yl)ethyl]-1-methylimidazole)]

Guidance literature:: In dichloromethane; ligand was added to soln. (PdCl(CH3)(COD)) in CH2Cl2 and stirred for 0.5h; soln. was filtered, solvent was removed in vacuo, residue was washed with Et2O and dried under vac.; elem. anal.;
DOI:10.1021/om0104363