1,4-Dioxaspiro[4.5]decane-6-acetic acid, 6-(phenylmethoxy)-, (6R)-

Base Information

Chemical Name:1,4-Dioxaspiro[4.5]decane-6-acetic acid, 6-(phenylmethoxy)-, (6R)-
CAS No.:337974-91-1
Molecular Formula:C17H22O5
Molecular Weight:306.359
Hs Code.:

Synonyms:

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Chemical Property of 1,4-Dioxaspiro[4.5]decane-6-acetic acid, 6-(phenylmethoxy)-, (6R)-

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Technology Process of 1,4-Dioxaspiro[4.5]decane-6-acetic acid, 6-(phenylmethoxy)-, (6R)-

There total 5 articles about 1,4-Dioxaspiro[4.5]decane-6-acetic acid, 6-(phenylmethoxy)-, (6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 442687-19-6
(2R,1'R)-2-acetoxy-3-(1'-benzyloxy-1'',4''-dioxaspiro[4.5]decyl)propionitrile

: 337974-91-1
(R)-2-(1'-benzyloxy-1'',4''-dioxaspiro[4.5]decyl)ethanoic acid

Guidance literature:: (2R,1'R)-2-acetoxy-3-(1'-benzyloxy-1'',4''-dioxaspiro[4.5]decyl)propionitrile; With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 16h;
DOI:10.1016/S0040-4039(01)00086-7

Reference yield:

: 36713-55-0
(±)-2-benzyloxycyclohexanone

: 337974-91-1
(R)-2-(1'-benzyloxy-1'',4''-dioxaspiro[4.5]decyl)ethanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: silica gel; basic aluminum oxide / cyclohexane / 4 h / 20 °C

2.1: 36 h / 20 °C

3.1: 8.32 g / acetic acid / H₂O; tetrahydrofuran / 4 h / 20 °C

4.1: 80 percent / TMSOTf / CH₂Cl₂ / -78 - 20 °C

5.1: LiOH / tetrahydrofuran / 1 h / 20 °C

5.2: 75 percent / 2-methyl-2-butene; Na₂HPO₄; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 20 °C

With aluminum oxide; lithium hydroxide; trimethylsilyl trifluoromethanesulfonate; silica gel; acetic acid; In tetrahydrofuran; dichloromethane; cyclohexane; water; 2.1: Michael addition;
DOI:10.1002/ejoc.200300111

Reference yield:

: 337974-89-7
[2-Benzyloxy-cyclohex-(E)-ylidene]-((R)-1-phenyl-ethyl)-amine

: 337974-91-1
(R)-2-(1'-benzyloxy-1'',4''-dioxaspiro[4.5]decyl)ethanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 36 h / 20 °C

2.1: 8.32 g / acetic acid / H₂O; tetrahydrofuran / 4 h / 20 °C

3.1: 80 percent / TMSOTf / CH₂Cl₂ / -78 - 20 °C

4.1: LiOH / tetrahydrofuran / 1 h / 20 °C

4.2: 75 percent / 2-methyl-2-butene; Na₂HPO₄; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 20 °C

With lithium hydroxide; trimethylsilyl trifluoromethanesulfonate; acetic acid; In tetrahydrofuran; dichloromethane; water; 1.1: Michael addition;
DOI:10.1002/ejoc.200300111