Cyclohexaneacetic acid, 2-oxo-1-(phenylmethoxy)-, methyl ester, (1R)-

Base Information

Chemical Name:Cyclohexaneacetic acid, 2-oxo-1-(phenylmethoxy)-, methyl ester, (1R)-
CAS No.:337974-93-3
Molecular Formula:C16H20O4
Molecular Weight:276.332
Hs Code.:

Synonyms:

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Chemical Property of Cyclohexaneacetic acid, 2-oxo-1-(phenylmethoxy)-, methyl ester, (1R)-

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Technology Process of Cyclohexaneacetic acid, 2-oxo-1-(phenylmethoxy)-, methyl ester, (1R)-

There total 6 articles about Cyclohexaneacetic acid, 2-oxo-1-(phenylmethoxy)-, methyl ester, (1R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 337974-92-2
methyl (R)-2-(1'-benzyloxy-1-'',4''-dioxaspiro[4.5]decyl)acetate

: 337974-93-3
methyl (R)-(1'-benzyloxy-2-oxocyclohexyl)acetate

Guidance literature:: With cerium(III) chloride; sodium iodide; In acetonitrile; at 80 ℃; for 18h;
DOI:10.1016/S0040-4039(01)00086-7

Reference yield:

: 36713-55-0
(±)-2-benzyloxycyclohexanone

: 337974-93-3
methyl (R)-(1'-benzyloxy-2-oxocyclohexyl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: silica gel; basic aluminum oxide / cyclohexane / 4 h / 20 °C

2: 36 h / 20 °C

3: 8.32 g / acetic acid / H₂O; tetrahydrofuran / 4 h / 20 °C

4: 80 percent / TMSOTf / CH₂Cl₂ / -78 - 20 °C

5: 61 percent / activated manganese dioxide; NaCN / 72 h / 20 °C

6: 85 percent / CeCl₃*7H₂O / NaI / acetonitrile / Heating

With manganese(IV) oxide; aluminum oxide; cerium(III) chloride; trimethylsilyl trifluoromethanesulfonate; sodium cyanide; silica gel; acetic acid; sodium iodide; In tetrahydrofuran; dichloromethane; cyclohexane; water; acetonitrile; 2: Michael addition;
DOI:10.1002/ejoc.200300111

Reference yield:

: 337974-89-7
[2-Benzyloxy-cyclohex-(E)-ylidene]-((R)-1-phenyl-ethyl)-amine

: 337974-93-3
methyl (R)-(1'-benzyloxy-2-oxocyclohexyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 36 h / 20 °C

2: 8.32 g / acetic acid / H₂O; tetrahydrofuran / 4 h / 20 °C

3: 80 percent / TMSOTf / CH₂Cl₂ / -78 - 20 °C

4: 61 percent / activated manganese dioxide; NaCN / 72 h / 20 °C

5: 85 percent / CeCl₃*7H₂O / NaI / acetonitrile / Heating

With manganese(IV) oxide; cerium(III) chloride; trimethylsilyl trifluoromethanesulfonate; sodium cyanide; acetic acid; sodium iodide; In tetrahydrofuran; dichloromethane; water; acetonitrile; 1: Michael addition;
DOI:10.1002/ejoc.200300111