337974-92-2

Upstream product

• 67-56-1 methanol 
• 442687-19-6 (2R,1'R)-2-acetoxy-3-(1'-benzyloxy-1'',4''-dioxaspiro[4.5]decyl)propionitrile 
• 332901-17-4 (2R,1'R)-2-acetoxy-3-[1'-benzyloxy-2'-oxocyclohexyl]propionitrile 
• 337974-89-7 [2-Benzyloxy-cyclohex-(E)-ylidene]-((R)-1-phenyl-ethyl)-amine 
• 36713-55-0 (±)-2-benzyloxycyclohexanone 

Downstream Products

• 337974-93-3 methyl (R)-(1'-benzyloxy-2-oxocyclohexyl)acetate 

Relevant academic research and scientific papers

Enantioselective synthesis of the ester side chain of homoharringtonine

Details of the synthesis of the methyl ester of the side chain of homoharringtonine, a natural product with antileukemic properties, are reported below. The key tactical element involved a Michael addition between the known chiral imine 4 and 2-acetoxyacr

Enantioselective synthesis of the ester side chain of homoharringtonine

The Michael adduct 6 was converted in ten steps with an overall yield of 5.7% into the methyl ester derivative of the side chain of homoharringtonine, (R)-17.