2-pyridin-2-yl-6-trifluoromethyl-pyrimidin-4-ol

Base Information

• Chemical Name: 2-pyridin-2-yl-6-trifluoromethyl-pyrimidin-4-ol
• CAS No.: 338404-77-6
• Molecular Formula: C10H6F3N3O
• Molecular Weight: 241.16900
• Hs Code.: 2933990090
• Mol file: 338404-77-6.mol

Synonyms:2-(pyridin-2-yl)-6-(trifluoromethyl)pyrimidin-4-ol;2-(2-Pyridinyl)-6-(trifluoromethyl)-4-pyrimidinol;4-hydroxy-2-(pyrid-2-yl)-6-(trifluoromethyl)pyrimidine;4-hydroxy-2-(2-pyridinyl)-6-trifluoromethyl-pyrimidine;

Chemical Property of 2-pyridin-2-yl-6-trifluoromethyl-pyrimidin-4-ol

Chemical Property:

• Melting Point: 137～138℃
• PSA: 58.90000
• LogP: 2.26300
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-2-(pyrid-2-yl)-6-(trifluoromethyl)pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-pyridin-2-yl-6-trifluoromethyl-pyrimidin-4-ol

There total 2 articles about 2-pyridin-2-yl-6-trifluoromethyl-pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.2%

ethyl 4,4,4-trifluoro-2-butynate (79424-03-6) + pyridine-2-carboxamidine hydrochloride (51285-26-8,61097-49-2) → 4-hydroxy-2-(2-pyridinyl)-6-trifluoromethyl-pyrimidine (338404-77-6)

Guidance literature:

With potassium hydroxide; concentrated aqueous KOH; In ethanol; water;

Reference yield:

pyridine-2-carboxamidine hydrochloride (51285-26-8,61097-49-2) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 4-hydroxy-2-(2-pyridinyl)-6-trifluoromethyl-pyrimidine (338404-77-6)

Guidance literature:

pyridine-2-carboxamidine hydrochloride; With ethanol; sodium; at 45 ℃; for 1h; Heating / reflux;

ethyl 4,4,4-trifluoroacetoacetate; In ethanol; for 5h; Heating / reflux;

Reference yield: 86.0%

4-hydroxy-2-(2-pyridinyl)-6-trifluoromethyl-pyrimidine (338404-77-6) → 4-chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine (438249-84-4)

Guidance literature:

With trichlorophosphate;

upstream raw materials:

ethyl 4,4,4-trifluoro-2-butynate

pyridine-2-carboxamidine hydrochloride

ethyl 4,4,4-trifluoroacetoacetate

Downstream raw materials:

4-chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine