Chemical Property of 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone
Chemical Property:
- Melting Point:289 °C
- Boiling Point:522.5±60.0 °C(Predicted)
- PKA:9.91±0.20(Predicted)
- PSA：82.92000
- Density:1.57±0.1 g/cm3(Predicted)
- LogP:3.98980
- Storage Temp.:Store at -20°C
- Solubility.:DMSO: >20mg/mL
- XLogP3:4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:2
- Exact Mass:351.9840041
- Heavy Atom Count:22
- Complexity:465
- Purity/Quality:
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99%, *data from raw suppliers
Mdivi 1 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl
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Description
Mdivi 1 is a mitochondrial division inhibitor. It inhibits the GTPase activity of yeast, but not human, dynamin-1 (Dnm1; IC50 = ~1-10 μM for the recombinant yeast enzyme) and human dynamin-related protein 1 (DRP1) in A549 lung cancer cells when used at a concentration of 50 μM. Mdivi 1 (50 μM) inhibits mitochondrial fragmentation and DRP1 self-assembly induced by staurosporine in COS cells overexpressing DRP1. It induces apoptosis in, and inhibits colony formation of, A549 cells when used at concentrations of 25 and 50 μM, respectively. Mdivi 1 (1 μM) decreases doxorubicin-induced increases in infarct-to-risk ratios in a Langendorff isolated perfused rat heart model of ischemia-reperfusion injury. It reduces the severity of lung injury in a mouse model of LPS-induced acute lung injury when administered at a dose of 20 mg/kg.
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Uses
Mdivi-1 is an inhibitor of mitochondrial division DRP1 and Dynamin I. Mdivi-1 has been used:in embryonic thoracic aorta A7r5 cells to inhibit cell migration and proliferationin mitochondrial network reshaping and reactive oxygen species (ROS) production studies in oligodendrocyte precursor cells (OPCs)to induce mitochondrial damage in lung fibroblasts
